Dr. Eliška Procházková

Dr. Eliška Procházková

Working area(s)

  • Postdoc 01/16 - 12/16

Field of research

  • NMR spectroscopy of organic molecules: nulceosides, nucleotides, peptides, viologens, azodyes, etc.
  • structure determination and conformational analysis
  • NMR parameters calculation
  • molecular interactions

Education

02 – 06 Secondary School, Masaryk Secondary School of Chemistry, Prague, CZ
06 – 09 Study of Biochemistry B. Sc., Faculty of Science, Charles University, Prague, CZ
09 – 11 Study of Biophysical Chemistry M. Sc., Faculty of Science, Charles University, Prague, CZ
11 – 15 Doctoral study of Physical Chemistry Ph. D., Faculty of Science, Charles University, Prague, CZ

Bachelor thesis

Title The Life Cycle and Metabolic Pathways of the Etiological Agent of Malaria and the Design of a Potential Inhibitor of Hypoxanthin-Guanin-Xanthin-Phosphoribosyltransferase
Group Prof. Dr. Antonín Holý
Place Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, CZ

Master thesis

Title Antioxidative Effects of the Analogues of Nucleic Acid Components
Group Dr. Helena Mertlíková-Kaiserová
Place Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prag, CZ

Ph. D. thesis

Title The Structure and Properties of Modified Nucleic Acid Components
Group Dr. Martin Dračínský
Place Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prag, CZ

Publications

1 H. Mertlíková-Kaiserová, M. Rumlová, E. Tloušťová, E. Procházková, A. Holý, I. Votruba
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG
Biochem. Pharmacol. 2011, 82, 131-138.
2 P. Jansa, O. Baszczyňski, E. Procházková, M. Dračínský, Z. Janeba
Microwave-assisted hydrolysis of phosphonate diesters: an efficient protocol for the preparation of phosphonic acids
Green Chem. 2012, 14, 2282-2288.
3 E. Procházková, P. Jansa, M. Dračínský, A. Holý, H. Mertlíková-Kaiserová
Determination of the antioxidative activity of substituted 5-aminopyrimidines
Free Rad. Res. 2012, 46, 61-67.
4 E. Procházková, P. Jansa, A. Březinová, L. Čechová, H. Mertlíková-Kaiserová, A. Holý, M. Dračínský
Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening
Bioorg. Med. Chem. Lett. 2012, 22, 6405-6409.
5 E. Procházková, M. Šála, R. Nencka, M. Dračínský
C6-substituted purine derivatives: an experimental and theoretical 1H, 13C and 15N NMR study
Magn. Reson. Chem. 2012, 50, 181-186.
6 E. Procházková, L. Čechová, P. Jansa, M. Dračínský
Long-range heteronuclear coupling constants in 2,6-disubstituted purine derivatives
Magn. Reson. Chem. 2012, 50, 295-298.
7 M. Dračínský, E. Procházková, J. Kessler, J. Šebestík, P. Matějka, P. Bouř
Resolution of Organic Polymorphic Crystals by Raman Spectroscopy
J. Phys. Chem. B 2013, 117, 7297-7307.
8 E. Procházková, L. Čechová, Z. Janeba, M. Dračínský
A Switchable Intramolecular Hydrogen Bond in Polysubstituted 5-Nitrosopyrimidines
J. Org. Chem. 2013, 78, 10121-10133.
9 L. Čechová, E. Procházková, I. Císařová, M. Dračínský, Z. Janeba
Separation of planar rotamers through intramolecular hydrogen bonding in polysubstituted 5-nitrosopyrimidines
Chem. Commun. 2014, 50, 14892-14895.
10 M. Dejmek, H. Hřebabecký, M. Šála, M. Dračínský, E. Procházková, P. Leyssen, J. Neyts, J. Balzarini, R. Nencka
From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus
Bioorg. Med. Chem. 2014, 22, 2974-2983.
11 M. Dejmek, M. Šála, P. Plačková, H. Hřebabecký, L. Mascarell Borredà, J. Neyts, M. Dračínský, E. Procházková, P. Jansa, P. Leyssen, H. Mertlíková-Kaiserová, R. Nencka
Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position
Arch. Pharm. Chem. Life Sci. 2014, 347,478-485.
12 M. M. Kaiser, D. Hocková, T.-H. Wang, M. Dračínský, L. Poštová-Slavětínská, E. Procházková, M. D. Edstein, M. Chavchich, D. T. Keough, L. W. Guddat, Z. Janeba
Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases
ChemMedChem 2014, 10, 1707-1723.
13 M. Dejmek, M. Šála, H. Hřebabecký, M. Dračínský, E. Procházková, D. Chalupská, M. Klíma, P. Plačková, M. Hájek, G. Andrei, L. Naesens, P. Leyssen, J. Neyts, J. Balzarini, E. Boura, R. Nencka
Norbornane-based nucleoside and nucleotide analogues locked in North conformation
Bioorg. Med. Chem. 2014, 23, 184-191.
14 I. Mejdrová, D. Chalupská, M. Kögler, M. Šála, P. Plačková, A. Baumlová, H. Hřebabecký, E. Procházková, M. Dejmek, R. Guillon, D. Strunin, J. Weber, G. Lee, G. Birkus, H. Mertlíková-Kaiserová, E. Boura, R. Nencka
Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action
J. Med. Chem. 2015, 58, 3767–3793.
15 M. Šála, M. Dejmek, E. Procházková, H. Hřebabecký, J. Rybáček, M. Dračínský, P. Novák, Š. Rosenbergová, I. Rosenberg, R. Nencka
A New Analogue of Locked Cyclohexane Nucleic Acids
Synthesis 2015, 47, 2654-2662.
16 M. Dračínský, L. Čechová, P. Hodgkinson, E. Procházková, Z. Janeba
Resonance-assisted stabilisation of hydrogen bonds probed by NMR spectroscopy and path integral molecular dynamics
Chem. Commun. 2015, 51, 13986-13989.
17 H. Hřebabecký, E. Procházková, M. Šála, P. Plačková, E. Tloušťová, O. Barauskas, Y. J. Lee, Y. Tian, R. Mackman, R. Nencka
Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides
Org. Biomol. Chem. 2015, 13, 9300-9313.
18 M. Šála, M. Dejmek, E. Procházková, H. Hřebabecký, J. Rybáček, M. Dračínský, P. Novák, Š. Rosenbergová, J. Fukal, V. Sychrovský, I. Rosenberg, R. Nencka
Synthesis of locked cyclohexene and cyclohexane nucleic acids (LCeNA and LCNA) with modified adenosine units
Org. Biomol. Chem. 2015, 13, 2703-2715.
19 E. Procházková, L. Čechová, J. Tarábek, Z. Janeba, M. Dracinsky
Tunable push–pull interactions in 5-nitrosopyrimidines
J. Org. Chem. 2016, 81, 3780–3789.
20 M. Šála, M. Kögler, P. Plačková, I. Mejdrová, H. Hřebabecký, E. Procházková, D. Strunin, G. Lee, G. Birkus, J. Weber, H. Mertlíková-Kaiserová, R. Nencka
Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors
Bioorg. Med. Chem. Lett. 2016, 26, 2706–2712.
21 E. Procházková, A. Kolmer, J. Ilgen, M. Schwab, L. Kaltschnee, M. Fredersdorf, V. Schmidts, R. C. Wende, P. R. Schreiner, C. M. Thiele
Uncovering Key Structural Features of an Enantioselective Peptide-Catalyzed Acylation Utilizing Advanced NMR Techniques
Angew. Chem. 2016, 128, 15986–15991, Angew. Chem. Int. Ed. 2016, 55, 15754–15759.
22 I. Mejdrová, D. Chalupská, P. Plačková, C. Müller, M. Šála, M. Klíma, A. Baumlová, H. Hřebabecký, E. Procházková, M. Dejmek, D. Strunin, J. Weber, G. Lee, M. Matoušová, H. Mertlíková-Kaiserová, J. Ziebuhr, G. Birkus, E. Boura, R. Nencka
Rational design of novel highly potent and selective phosphatidylinositol 4-kinase IIIβ (PI4KB) inhibitors as broad-spectrum antiviral agents and tools for chemical biology
J. Med. Chem. 2016, 60, 100-118.
23 H. Hřebabecký, M. Dračínský, E. Procházková, M. Šála, R. Mackman, R. Nencka
Control of α/β Anomer Formation by a 2′,5′ Bridge: Toward Nucleoside Derivatives Locked in the South Conformation
J. Org. Chem. 2017, 82, 11337-11347.
24 K. Bártová, L. Čechová, E. Procházková, O. Socha, Z. Janeba, M. Dračínský
Influence of Intramolecular Charge Transfer and Nuclear Quantum Effects on Intramolecular Hydrogen Bonds in Azopyrimidines
J. Org. Chem. 2017, 82, 10350-10359.
25 E. Procházková, L. Čechová, J. Kind, Z. Janeba, C. M. Thiele, M. Dračínský
Photoswitchable intramolecular hydrogen bonds in 5-phenylazopyrimidines revealed by in-situ irradiation NMR spectroscopy
Chem. Eur. J. 2018, 24, 492-498.