Announcements

Chemie fuer Schueler – Organische Chemie

Chemie fuer Schueler – Organische Chemie

 

Seminars

 

SS 2009

26.03.09 Thomas Kramer Part B, Ch. 9 Finding a lead:
16.04.09 Alexander Boländer Part B, Ch. 10 Drug Design, PNAS Zhang Interprotofilament
23.04.09 Nicole Höttecke Part B, Ch. 11 Optimization
30.04.09 Daniel Kieser Part B, Ch. 12 Development
07.05.09 Andrea Zall Part B, Ch. 13 QSAR
How to beat an alcohol problem Nature 2008, 456, p.711, p.77
14.05.09 Azadeh Nazari Part C, Ch. 14 Combichem
28.05.09 Koolman Part C, Ch. 15 Compuchem
04.06.09 B.I. Spinnenseide
09.06.09   Merck Lecture 4x
18.06.09 O. Müller Part D, Ch. 17 Antivirals
25.06.09   BMBF Summerschool
02.07.09 Thomas Kramer Part D, Ch. 18 Anticancer & Byrostatin in Nature 2008, 456, 485 highlight
09.07.09 F. Gerstmann
F. Lo Monte
Part D, Ch. 16 Antibacterials
Therapeutic application of histone deacetylase inhibitors for CNS
28.08.09   Auguste Deter Gedächtnis-Seminar: Tau entangles in the trees
30.08.-03.09.09   GDCh-Wissenschaftsforum, Frankfurt

WS 2009/10

01.10.09 Nicole Höttecke Part D, Ch. 19 Cholinergics
08.10.09 Alexander Boländer Part D, Ch. 20 Adrenergics
15.10.09 Boris Schmidt Neuroleptika
29.10.09 Fabio Lo Monte Part D, Ch. 21 Opium analgesics, Abbot ABT594 + Epibatidin
19.11.09 Daniel Kieser Part D, Ch. 22 Antiulcer
   Totalsynthesen, Synthesemethoden, Biochemie
26.11.09 Thomas Kramer Akt Inhibitor X: linked via mTOR to GSK3?
05.11.-06.11.09 N. Höttecke, D. Kieser, F. Lo Monte Neuro GSK3
17.12.09   X-Mas Seminar
14.01.10   BMBF Seminar München
21.01.10 Andrea Zall
Azadeh Nazari
Total Synthesis of Hirsutellone B. Angew. Chem. 2009, 121, 7002 Tricyclische Antidepressive. ChiuZ 2008, 206 & Carbozolsynthese-Review H.-J. Knöler Chem. Rev. 2002, 4303 Top Curr Chem

SS 2010

   Imaging and Lipids
15.04.10 Dr. S. Kolb CDC25 + An Efficient Method Based on the Photothermal Effect for the Release of Molecules from Metal Nanoparticle Surfaces. Angew. Chem. 2009, 4230 Nature 2010 Hyman in Press
22.04.10 Jiamin Gu Imaging Neurodegeneration in Parkinsons' Disease. Biochimica et Biophysica Acta 2009, 457, 573
29.04.10 Binia Thomaszewski Drug-Phospholipid Interaction. ChemMedChem 2009, 4(8), 1224 MCT1 Transporter and BBB
06.05.10 Andrea Zall Chlorinated Lipids associated with seafood poisoning.Nature 2009, 457, 548, Nature 2009, 457, 573
20.05.10 Daniel Kieser Hochauflösende Mikroskopie mit kleinen organischen Farbstoffen. Angew. Chemie 2009, 121, 7036
27.05.10 Alexander Boländer Labelling of Terminal Cysteine Residues. Angew. Chem. 2009, 121, 9838
Photoswitching of Cyanine Dyes. JACS 2010
10.06.10 Thomas Kramer nicht ATP-kompetitive Kinase-Inhibitoren
17.06.10 Azadeh Nazari  
24.06.10 Eva Fuchs BACE Inhibitoren
01.07.10 Fabio Lo Monte Resveratrol and Sirtuins. C&EN 2009, 14.12.
08.07.10 Upendra Anumala STED/PALM Microscopy – switchable dyes

WS 2010/11

07.10.10 Jiamin Gu
Matthias Fach
(8+2) Cycloaddition – Review, Application and Optimisation
GSK3 Inhibition
04.11.10 Binia Thomaszewski plos one 2010, 5, e9505 S.J. Soscia et al.
Abeta is an antimicrobial peptide
18.11.10 Daniel Kieser AD Imaging. Okamura et al. J. Neuroscience 2005, 25, 10857
25.11.10 Eva Naumann Auguste Deter Einweisungssymposium!
HDAC6 Inhibitoren: Leitstrukturen, Synthese und Selektivität
02.12.10   X-Mas Seminar
20.01.11 Alexander Boländer Parkinson's Disease: Diagnostics & Therapy. Nature 2010, 466, S1 (26.08.), reMynd
27.01.11 Thomas Kramer LRRK2 Inhibitors
27.01.11 Daniel Kieser AD Imaging
03.02.11 Andrea Zall Photocrosslinking to proteins

SS 2011

12.05.11 Fabio Lo Monte
Karl Gatterdam
Z-Enolether synthesis GSM
19.05.11 Constantin Voss
Jiamin Gu
GrK SB – Assayplan und Referenzstubstanzen
Drug Membrane Interactions. J.K. Seydel focus on Nile red
16.06.11 Eva Naumann
Upendra Anumala
HDAC 2/6 Assays, Tiermodelle und neue Zn-koordinierende Motive J-Aggregates. Angew. Chemie 2011, 3376
22.06.11 Dennis Bensinger Neue Motive für das 20 S Proteasom. E. J. Med. Chem 2011
11.08.11 A. Nazari, M. Brodrecht, J. Pilakoswki Trifluoromethylation, Angew. Chemie. 2011, 3877
B.Sc. Vorträge
18.08.11 B. Thomaszewski
Andrea Zall
APOE Strukturen und Ab, J. Biol.Chem. 2007, 1073, 281.
PEG beim Wirkstofftransport. Angew. Chem. 2010, 6430
25.08.11 Thomas Kramer Daniel Rauh: Stabilizing Inactive Kinases. Arch. Pharm, 2010, 3434, 193, NCTL, 2010, 118
01.09.11 Alexander Boländer B. Yousefi et al. J. Med. Chem. 2011, 54(4), 949-956 Öancet 2011, Florbetaben, Neuroimage 2011, 54, S204-217

WS 2011/12

06.10.11 Sarah Albrecht Transparente Fische für die Fluoreszenzmikroskopie, Scale: transparent mouse brain. Nature Neuroscience 2011
20.10.11 Fabio Lo Monte Aromatische Ringe in chemischer und biologischer Erkennung. Angew.Chemie,2011, 4908
17.11.11 Alexander Boländer 2-Photon absorption properties of fluorescent proteins. Nature Methods,2011, 8, 393
Characterization of prefibrillar tau oligomers… J.Biol.Chem2011
24.11.11 Stefan Göring MKK4, a druggable target? Mol Cell Biochem Czech et al 2011
Pd-kat Kreuzkupplung Heteroarene. Angew. Chem. 2001, 123, 7618
Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 2011, 477, 107
24.11.11 Thomas Kramer Praktische Eintopfsynthese. Angew. Chem. 2011, 7428
01.12.11 Andrea Zall Crystal structure of the ab p3. J. Neuroscience 2011, 31, 1419
01.12.11 Constantin Voss Fluorescent and luminescent probes for the detection of ROS.Chem.Soc.Rev. 2011, 40, 4783
08.12.11 Jiamin Gu Dye-sensitized solar cells. Chemistry EJ 2011
Cynain dye T-284 and synuclein. J. Fluoresence 2010, 20, 1267
12.01.12 Eva Naumann Störung von Histon-Ablesern. Angew. Chem. 2011, 123, 5921
Charcot-Marie Tooth disease
12.01.12 Upendra Anumala Light microscopy with doghnut modes. Angew. Chem. 2011, 5274
19.01.12 Binia Thomaszewski Kristalline Lipiddomänen. Angew. Chem. 2011, 123, 3700
Protein membrane anchorage. Angew. Chem. 2011, 123, 6327
02.02.12 Azadeh Nazari Dyrk1A Inhibitors SAR. PlosOne 2011, e19264

SS 2012

19.04.12 Stefan Göring Synuclein Dyes. Histology of Parkinson's disease
26.04.12 Christoph Scholz
Matthias Fach
Multiple myeloma and the proteasome. Nature 2011, 480, 833ff
Proteasom regulation. Nature 2012, 482, 170 & 186
FLT3 Inhibition
Targeting protein kinases in central nervous system disorders Nature Drug Discovery 2009, 8, 892
10.05.12 M. BME Dyrk1
24.05.12 Constantin Voss Die Chemie und der Wurm Angew. Chem. 2011, 4870
Tumor bearing chick-embryo J. Rad. Res. 2011, 52, 208
Cyclin D1 multitasks Nature 2011, 474, 171 + 230
Cyclin D1 ligands, antagonists?
Hyper I-III ROS sensitive proteins
31.05.12   
07.06.12 Eva Naumann



Theresa Neumann
Amphoterin B and analogues
Protein templated Click chemistry Angew. Chem. 2010, 122, 6969
Metabolic labelling
14.06.12 Upendra Anumala Trifluromethylation of arenes and heteroarenes by means of photoredox catalysis Nature 2011, 224
Proteasome Inhibition
14.06.12 Binia Drung P. Knochel Regio- und chemoselektive Metallierung Angew. Chem. 2011, 9968
21.06.12 Jiamin Gu

Upendra Anumala
Review Jeff Kuret, synuclein dyes, J/H, Vokova et al.
Shuttle medicated drug delivery to the brain. Angew. Chem. 2011, 50, 7998
28.06.12 Christoph Scholz Proteasom-Inhibitoren
05.07.12 Matthias Fach Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hing Binding Mode. ACS Med. Chem. Lett. 2012
12.07.12 Azadeh Nazari  

WS 2012/13

08.11.12 Upendra Anumala H.C. Kolb: A highly selective and specific PET Tracer for Imaging of Tau Pathologies. J. Alz. Dis. 2012, 31, 1-12
15.11.12 Prof. Kloetzel 17.00-18.30 Graduiertenkolleg, FB Biologie
22.11.12 Jiamin Gu Jeff Kuret et al: Ligand electronic properties modulate tau filament binding site density. sciencedirect
29.11.12 PD Dr. Gaipl 17.00-18.00 Uhr Graduiertenkolleg, FB Biologie
29.11.12 Valeria Barbosa Carbolines from Arylazides Angew. Chem. 2012, 124, 6022
13.12.12 PD Dr. Gaipl 17.00-18.00 Uhr Graduiertenkolleg, FB Biologie
17.01.13 Stefan Göring Validation of ITD mutations in FLT3 as a therapeutic target Nature 2012, 485, 260
Reagentless Oxidative Folding Angew. Chem. 2012, 124, 5678
Strategic use of non-native diselenide bridges Angew. Chem. 2012, 124, 5683
24.01.13 Binia Drung Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode. ACS Med. Chem. Lett. 2012
Catalyst-Controlled Chemoselective Arylation of 2-Aminobenzimidazoles Angew. Chem. Chem. 2012
24.01.13 Eva Naumann


Theresa Neumann
A breach in the Blood Brain Barrier. Nature 2012, 485, 451 + 452
Ohne dirigierende Gruppen: übergangsmetallkatalysierte C-H-Aktivierung Angew. Chem. 2012, F. Glorius
31.01.13 Constantin Voss Spurlose Triazolsynthese. Angew. Chem. 2012, 124, 5437
Activation of remote meta-C-H bonds assisted by an en-on template Nature 2012, 486, 518
07.02.13 Boris Schmidt Fragment based Approaches in Drug Discovery and Chemical Biology. Biochemistry 2012, 51 (25), 4990-5003
14.02.13 Dennis Bensinger Chemical Protein Synthesis by Chemoselective a-Ketoacid-Hydroxylamine (KAHA) Ligations with 5-Oxaproline Angew. Chem. 2012, 5114

SS 2013

11.04.13 Steven Smith M.Sc. Thesis: Novel core motics for kinase inhition
18.04.13 Theresa Neumann M.Sc Thesis: Improved GSK3 Inhibitors
25.04.13 Parul Goel Membrane immersion allows rhomboid proteases to achieve specificity by reading transmembrane segment dynamics eLife 2012
25.04.13 Stefan Göring Progressive degeneration of human neural stem cells caused by pathogenic LRRK2 Nature 2012, 491, 603
Demystifying Brain Penetration in Central Nervous System Drug Discovery. J. Med. Chem, 2013, 56, 2-12
02.05.13 Eva Naumann Structure of a presenilin family intramembrane aspartane protease Nature 2013, 493, 56 34
Modulators of -Secretase Activity Can Facilitate the Toxic Side-Effects and Pathogenesis of Alzheimer's Disease. PlosOne 2013
02.05.2013 Binia Drung Wechselwirkungen zwischen amyloidogenen Proteinen und Membranen. Angew. Chem. 2010, 122, 5760-5788
16.05.2013 n. n. Theresa Leutzsch
23.05.2013   Oberseminar
03.06.-07.06.2013 Binia Drung
Constantin Voss
GrK Retreat, Hirschegg
13.06.2013 Constantin Scholz


Theresa Neumann




EU Horizon 2020
Bacterial proteolytic complexes Nature Rev. Drug Dis. 2012, 11, 77
JNK3 as a new target in AD? Nature Drug Discovery 2012, 11, 829
Synthese aromatischer Nitrile mithilfe nichtmetallischer CN-Quellen Angew. Chem. 2012, 124, 2114.
Darmstadtium
13.30-18.30 Uhr
20.06.2013 Constantin Voss
Karen Voehringer


F. Anders/T. Lotz
Reducing safety-related drug attrition: The use of in vitro pharmalogical profiling Nature Reviews Drug Discovery 2012, 11, 909-922

Botox Assay
MBME Abschlussvortrag: iProteasom
27.06.2013 V. Spieler, J. G. M. BME Abschlussvortrag: NEK1
04.07.2013 J. Pilakowsky M. BME Abschlussvortrag: NEK1, Rhomboid
18.07.2013 Liebig, Babel M. BME Abschlussvortrag: FLT3
01.09.-04.09.2013   GDCh Tagung, Darmstadt

WS 2013/14

31.10.2013 Theresa Neumann
Binia Drung
Metalated Indoles, Indazoles, Benzimidazoles and Azaindoles and their Synthetic Applications. Synthesis 2013, 2343

Self-propagation of pathogenic protein aggregates in neurodegenative disease Nature 2013, 501, 45
14.11.2013 Johannes Pilakowski Master Thesis Presentation
28.11.2013 Constantin Voss
Christoph Scholz
ALS – Motorneuron degradation & targets for drug development, TDP-43
09.12.-11.12.2013 Binia Drung
Constantin Voss
GrK Retreat, Trifels
05.12.2013 Parul Goel Rhomboid Inhibitors Own Results
19.12.2013   X-Mas Seminar
16.01.2014 Eva Naumann Abschlussvortrag
23.01.2014 Dennis Bensinger Stereoinversion of tertiary alcohols to tertiary-alkyl isonitriles and amines. Nature 2013, 501, 195.
30.01.2014 Stefan Göring Platforms for antibiotic discovery DOI: 10.1038/NRD3975
06.02.2014   
13.02.2014