Alesia A. Tietze Home

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What we are interested in…

A major focus of our research is the total synthesis of complex molecules, i.e. cysteine-rich peptides, which are derived from biologically active natural sources (i.e. cone snails, spiders, snakes), their targets (membrane proteins) and their structural analogues. We study the neurotoxins mode of action, i.e. peptide/protein-lipid-interaction, with their counterparts, i.e. membrane proteins or/and transmembrane receptors by NMR spectroscopy (collaboration partners). For this purpose we develop new strategies for the chemical synthesis of membrane proteins (ion channels), since their synthesis is challenging due to their highly hydrophobic properties. We develop methods to improve their solubility and therefore facilitate the availability of this class of proteins/peptides. Chemical synthesis of membrane proteins (ion channels) is an advantageous method primary because synthetic peptides can be customized[1] (i.e. isotopic labeling) and derivatized (i.e. incorporation of post-translational modifications) depending on the purpose of the research. Moreover, the amount of compounds produced by chemical synthesis allows development of bio-inspired smart nanochannels.[2]

[1] T. Sato, Biopolymers 2015.

[2] X. Hou, L. Jiang, ACS nano 2009, 3, 3339-3342.


01/2019 We are currently recruiting post-docs:

Postdoc in chemical synthesis of bioactive peptides and membrane-associated proteins (within 3 years after PhD)

Postdoc in chemical synthesis of switchable peptide-based nanopores (within 3 years after PhD)

Researcher in structure and function of peptide-based toxins (>3 years after PhD)
10/2018 Alesia has accepted an appointment as Associate Senior Lecturer in Medicinal Chemistry at Wallenberg Centre for Molecular and Translational Medicine, Department of Chemistry and Molecular Biology at the University of Gothenburg, Göteborg, Sweden
09/2018 Poster Prize at the 35th European Peptide Symposium in Dublin, Ireland

Our lab’s research on membrane proteins and the development of a ligation strategy towards quantitative synthesis of these structures gained great interest at the 35th EPS 27.08-31.08.2018 in Dublin, Ireland. Lena was awarded one of the three Wiley Poster Prizes (200 €) for her poster presentation, congratulations!
07/2018 Gratulations to Lena who won „Best Talk Award“ at the PhD student day of the chemistry department of the TU Darmstadt on June 28th with her presentation on “Hybrid Nanopores as an Effective Sensing Tool for Early Diagnostics of Alzheimer's Disease”. We kindly thank the chairman Dr. Andreas Geißler and his team for the organization of this academic meeting.
01/2018 Our new manuscript about the synthesis of membrane proteins has been accepted for Publishing in Chemical Science:

Chemical synthesis of membrane proteins by native chemical ligation: a model study on the influenza virus B proton channel

Baumruck, A. C., Tietze, D., Steinacker, L. K., Tietze A. A.*, 2018, DOI: 10.1039/C8SC00004B
06/2017 „Our new manuscript about some intriguing properties of ILs has just been accepted for publishing in JOC: “Reactions of sulfur-containing organic compounds and peptides in 1-ethyl-3-methyl-imidazolium acetate”

Baumruck, Andreas; Tietze, Daniel; Stark, Annegret; Tietze, Alesia*“
03/2017 Alesia is appointed as TU Darmstadt Athene Young Investigator
02/2017 Andreas was a selected participant at the Winter School on Ionic Liquids (within COST CM1206) on February 7 – 10, 2017 in Porto, Portugal.
The main goal of this school was to deliver a cross-disciplinary learning approach and condensed overview in the field of ionic liquids with emphasis on State of the Art, R&D methodologies, functionalities and applications. The lectures were problem-solving oriented emphasizing case studies of relevance to properties, characteristics of the ionic liquids and are specially geared towards novice scientists in the ILs field.
12/2016 Subtype-specfic block of voltage-gated K+ channels by µ-conopeptides, Biochemical and Biophysical Research Communications, is accepted for publication
11/2016 We warmly wellcome Jana Grensing, our new Master student!
07/2016 We warmly welcome our new PhD student Lena Steinacker to our research group!
06/2016 Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels, BBA General Subjects, is published
05/2016 Positive Evaluation of the Liebig-Fellowship. It is prolonged for the next funding period
01/2016 We are participating in the LOEWE Program for Scientific and Economic Excellence iNAPO (Ion-conducting Nanopores)