Hydrogel matrices

Hydrogel Matrices For Sensing and Cell Growth (finished)

Dextrane-based pH-responsive polymers can be transformed into hydrogel films by using benzophenone as crosslinker and for attachment to a substrate. The as-prepared hydrogel films offer high and adjustable swelling degrees and carboxyl-groups as binding points for analyte recognition units. Especially, in combination with cold surfaces they can be used for sensing with near field modes such as surface plasmons and leaky waveguide modes. Prepared on glass or plastic surfaces they can be optimized as matrix for cell growth studies.

Related Publications:

A. Brunsen, U. Ritz, A. Mateescu, I. Höfer, P. Frank, B. Menges, A. Hofmann, P.M. Rommens, W. Knoll, U. Jonas, “Photocrosslinkable Dextran Hydrogel Films as Substrates for Osteoblast and Endothelial Cell Growth”, J. Mater Chem., 22, 19590, (2012).

A. Brunsen, U. Jonas, S. Utech, M. Maskos, W. Knoll, “Magnetic Composite Thin Films of FexOy Nanoparticles and Photocrosslinked Dextran Hydrogels”, Journal of Magnetism and Magnetic Materials, 324, 8, 1488, (2012).

Ulrich Jonas, Coenraad R. van den Brom, Annette Brunsen, Robert F. Roskamp; Review “Surface-Attached Polymeric Hydrogel Films”, book chapter in “Handbook of Biofunctional Surfaces”, edited by W. Knoll, Pan Stanford Publishing, Singapore, Print ISBN: 9789814316637, (2012).

Y. Wang, A. Brunsen, U. Jonas, J. Dostalek, W. Knoll, Anal. Chem., “Prostate Specific Antigen Biosensor Based on Long Range Surface Plasmon-Enhanced Fluorescence Spectroscopy and Dextran Hydrogel Binding Matrix”, Analytical Chemistry, 81, 23, 9625-9632, (2009).

W. Knoll, A. Kasry, F. Yu, Y. Wang, A. Brunsen, J. Dostalek, “New concepts with surface plasmons and nano biointerfaces, Journal of Nonlinear Optical Physics and Materials”, 17, 2, 121-129, (2008).

R. F. Roskamp, A. Brunsen, M. Gianneli, P. Jakubowicz, B. Menges, U. Jonas, G. Fytas, Wolfgang Knoll; “Hydrogels: Synthesis, Functionalization and Optical Investigation”, Polymer Preprints, 49 (1), 1018-1019, (2008)