Research, F. Hausch

The Hausch lab explores novel therapeutic concepts and innovative approaches to design better pharmacologically active compounds. In particular we pursue the following topics:

The Hausch lab explores novel therapeutic concepts and innovative approaches to design better pharmacologically active compounds. In particular we pursue the following topics:

  • Identification and validation of novel pharmacological concepts
  • Rational drug design of conformationally defined ligands
  • Synthesis of 3D-enriched macro- or polycyclic ligands
  • Quantitative understanding of protein-ligand interactions
  • Development of FKBP51 inhibitors as novel antidepressants, analgesics and/or anti-obesity agents
Bild: F. Hausch
Structure of FKBP51 (grey surface) in complex with iFit4 (cyan sticks), a prototypic selective antagonist of FKBP51 by induced fit. The cyclohexenyl group of iFit4 (highlighted in blue) induces a rearrangement of Phe67 (red sticks), which is the structural basis for the selectivity of this class of ligands for FKBP51 over the close homolog FKBP52. Ref: Gaali et al, Nat Chem Biol 2015; pdb-code: 4TW7