Welcome - AK Hausch

Welcome to the Hausch group!

Overview of Structure-based Drug Research:

  • Rational Drug Design
  • Identification and validation of novel pharmacological concepts
  • Synthesis of macro- or polycyclic substances to control the bioactive conformation
  • Quantitative understanding of protein-ligand interactions
  • Development of FKBP51 inhibitors as novel antidepressants, analgesics or anti-obesity agents

Recent News:

Publication on FKBP ligands as anti-infectives

Bild: F. Hausch
Structure of FKBP51 (grey surface) in complex with a prototypic bicyclic sulfonamide ligand (shown as sticks, carbons in cyan, oxygens in red, nitrogens in blue, sulfurs in yellow, cholrine in green). Hydrogens bond are indicated as dotted yellow lines. Ref: Pomplun et al, Angew Chem Int Ed 2015; pdb-code: 4W9P