Welcome - AK Hausch

Welcome to the Hausch group!

Overview of Structure-based Drug Research:

  • Rational Drug Design
  • Identification and validation of novel pharmacological concepts
  • Synthesis of macro- or polycyclic substances to control the bioactive conformation
  • Quantitative understanding of protein-ligand interactions
  • Development of FKBP51 inhibitors as novel antidepressants, analgesics or anti-obesity agents

Recent News:

03.04.2019

Work by the Hausch lab covered in a press conference at the ACS Spring meeting in Orlando

27.03.2019

Poster by Jürgen Kolos nominated for a short talk at the conference Frontiers in Medicinal Chemistry 2019. Congratulations!

01.12.2018 Fabian & Tim joint the lab. Welcome!

12.11.2018 New publications of FKBP51 on interaction with antidepressants and in human adipocytes

Bild: F. Hausch
Structure of FKBP51 (grey surface) in complex with a prototypic bicyclic sulfonamide ligand (shown as sticks, carbons in cyan, oxygens in red, nitrogens in blue, sulfurs in yellow, cholrine in green). Hydrogens bond are indicated as dotted yellow lines. Ref: Pomplun et al, Angew Chem Int Ed 2015; pdb-code: 4W9P