„Green“ Peptide Synthesis
Dating back to the very beginning of the XX century when Emil Fisher presented the first protocols for the synthesis of oligopeptides, peptide chemistry has been developed into a rapidly growing research field. The real breakthrough in the field of synthetic peptides was achieved when Bruce Merrifield has presented his concept of the solid-phase peptide synthesis (SPPS). Based on the convergent assembly of orthogonally protected amino acids on the insoluble polymeric support, this approach has really revolutionized the peptide branch and was honored with the Nobel Prize in 1984. Over the following three decades peptide chemistry has been significantly developed towards more and more efficient synthetic procedures, having taken advantage of the automation, novel protection strategies, microwave assistance, improved isolation and purification methods, as well as advanced analytics. In our group we are currently developing synthetic strategies allowing for controllable peptide assembly and successive purification following the principles of sustainable green chemistry.