Welcome to the homepage of the Lermyte lab. On these pages you will find information on the research, teaching, and members of the Conformation-Sensitive Mass Spectrometry laboratory at TU Darmstadt. You will also find news updates from the lab and information on opportunities to join our group, so make sure to check back here regularly!
While it would be ideal to have high-resolution structures available for all proteins, not all of them are amenable to conventional methods such as X-ray crystallography or nuclear magnetic resonance. These techniques also often sample either a single low-energy state or an “average” conformation, and therefore do not accurately reflect the full conformational space that a protein occupies. Mass spectrometry has evolved to the point where it is a nearly universally applicable technique that can provide significant structural information about challenging systems. In our laboratory, we work on the development of these methods, and also apply them to solve biological questions, often in collaboration with other researchers.