Being related to proteins, classical peptides consist of α-L-amino acids. However, growing interest in the design of special superstructures requires the use of other building blocks. Among such unnatural peptides those comprising β-amino acids are known to give stable secondary structures: mostly helices, but also β-sheet-like strands, etc. We elaborate the synthesis of β-amino acid derivatives and helical peptides in order to obtain new liquid crystalline phases for NMR/RDC structural analysis.

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1 C. M. Thiele, W. C. Pomerantz, N. L. Abott, S. H. Gellman, Lyotropic liquid crystalline phases from helical beta-peptides as alignment media, Chem. Commun. 2011, 47, 502-504 (Emerging Investigators Issue).