Lukas Kaltschnee – Arbeitskreis Thiele – TU Darmstadt

Der Arbeitskreis Thiele

Dr. Lukas Kaltschnee

Arbeitsgebiet(e)

Masterthesis 10/11 - 04/12, Promotion 06/12 - 08/16, Postdoc 01/24 - 06/25

Kontakt

lkaltschnee@thielelab.de

work +49 6151 16-21836

Work L207 5
Peter-Grünberg Straße 16
64287 Darmstadt

Forschungsgebiet

Charakterisierung von Stofftransport nahe Dreiphasenkontaktlinien mittels MRT (Teilprojekt A08 im SFB 1194 „Wechselseitige Beeinflussung von Transport- und Benetzungsvorgängen“)
Untersuchung von Wasserstoffkatalyse mittels Parawasserstoff-verstärkter NMR

Ausbildung & akademischer Werdegang

01/24 – 06/25	Postdoc, Technische Universität Darmstadt, Darmstadt, im Rahmen des SFB 1194
09/17 – 01/24	Postdoc, Max-Planck-Institut für Mulitdisziplinäre Naturwissenschaften (ehem. Max-Planck-Institut für Biophysikalische Chemie), Göttingen, bei Stefan Glöggler und Christian Griesinger
09/16 – 08/17	Postdoc, NIDDK/NIH, Bethesda, MD, USA, bei Adriaan Bax
07/14 – 09/14	Forschungsaufenthalt, University of Manchester, Großbrittanien, bei Gareth A. Morris
06/12 – 08/16	Promotion, Technische Universität Darmstadt, Darmstadt
10/11 – 04/12	Master-Thesis, Technische Universität Darmstadt, Darmstadt
06/11 – 09/11	Externe Hauptvertiefung, Max-Planck-Institut für Polymerforschung, Mainz, bei F. Laquai
04/10 – 04/12	Chemiestudium M. Sc., Technische Universität Darmstadt, Darmstadt Schwerpunktfach Physikalische Chemie
09/08 – 07/09	ERASMUS-Auslandsstudium, École Polytechnique Fédérale de Lausanne, Lausanne (Schweiz)
10/06 – 03/10	Chemiestudium B. Sc., Technische Universität Darmstadt, Darmstadt
09/05 – 05/06	Zivildienst, Frankfurter Verein für soziale Heimstätten e.V.
08/96 – 07/05	Gymnasialer Zweig, Philipp-Reis-Schule, Friedrichsdorf
08/92 – 07/96	Grundschule, Frankfurt a. M. und Friedrichsdorf

Bachelorthesis

Titel	Effect of Coadsorbents on the Performance of Dye Sensitized Solar Cells
Arbeitskreis	Prof. Dr. M. Grätzel
Ort	Faculté des Sciences de Base, École Polytechnique Fédérale de Lausanne; eingereicht am Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt

Masterthesis

Titel	Untersuchungen zur Quantifizierung 1H-entkoppelter protonendetektierter Experimente
Arbeitskreis	Prof. Dr. C. M. Thiele
Ort	Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Fachbereich Chemie, Technische Universität Darmstadt

Dissertation

Titel	Development and Evaluation of Experiments for Pure Shift Solution-State Magnetic Resonance Spectroscopy
Arbeitskreis	Prof. Dr. C. M. Thiele
Ort	Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Fachbereich Chemie, Technische Universität Darmstadt

Preise und Auszeichnungen

01/13 – 12/14	Promotionsstipendium der Merck'schen Gesellschaft für Kunst und Wissenschaft e.V.
09/16 – 02/18	P.R.I.M.E. Fellowship des Deutschen Akademischen Auslandsdienstes (DAAD)
02/17	Kurt-Ruths-Preis der Technischen Universität Darmstadt
06/17	Promotionspreis der Familie Bottling-Stiftung

Vorträge

1	Improving Signal Separation for Oligomeric Structures in Pure Shift HSQC Spectra GDCh FGMR 37th Annual Discussion Meeting, Darmstadt, 09/15. (upgraded poster)
2	CLIP-COSY: Rapid Acquisition of COSY-Type Correlation Spectra with In-Phase Signal Character 5th Annual Practical Applications of NMR in Industry Conference (PANIC 2017), Hilton Head Island/SC/USA, 02/17. (invited talk)
3	Hydrogen catalysis of the [Fe]-hydrogenase studied by parahydrogen enhanced NMR 43th FGMR Annual Discussion Meeting, Karlsruhe, 09/22. (upgraded poster)
4	Hydrogen catalysis of the [Fe]-hydrogenase studied by parahydrogen enhanced NMR Konstantin Ivanov Intercontinental Magnetic Resonance Seminar, online, 05/23.
5	Transient intermediates of [Fe]-hydrogenase catalysis studied by sensitivity-enhanced NMR 17th European Biological Inorganic Chemistry Conference (EuroBIC-17), Münster, 08/24.
6	Transient intermediates of [Fe]-hydrogenase catalysis studied by sensitivity-enhanced NMR CRC 1487 symposium „Understanding Iron & Friends“, Darmstadt, 09/24.

Publikationen

1	A. Kolmer, L. Kaltschnee, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on rotational barriers of bis-NHC-complexes as observed by dynamic NMR spectroscopy Magn. Reson. Chem. 2013, 51, 695–700.
2	I. Timári, L. Kaltschnee, A. Kolmer, R. W. Adams, M. Nilsson, C. M. Thiele, G. A. Morris, K. E. Kövér Accurate determination of one-bond heteronuclear coupling constants with “pure shift” broadband proton-decoupled CLIP/CLAP-HSQC experiments J. Magn. Reson. 2014, 239, 130-138.
3	L. Kaltschnee, A. Kolmer, I. Timári, V. Schmidts, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele „Perfecting“ pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings Chem. Commun. 2014, 50, 15702-15705.
4	M. R. M. Koos, G. Kummerlöwe, L. Kaltschnee, C. M. Thiele, B. Luy CLIP-COSY: A Clean Inphase Experiment for Rapid Acquisition of COSY-type Correlations Angew. Chem. 2016, 128, 7785-7789, Angew. Chem. Int. Ed. 2016, 55, 7655-7659.
5	L. Kaltschnee, K. Knoll, V. Schmidts, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Extraction of Distance Restraints from Pure Shift NOE experiments J. Magn. Reson. 2016, 271, 99-109.
6	I. Timári, L. Kaltschnee, M. H. Raics, F. Roth, N. G. A. Bell, R. W. Adams, M. Nilsson, D. Uhrín, G. A. Morris, C. M. Thiele, K. E. Kövér Real-time broadband proton-homodecoupled CLIP/CLAP-HSQC for automated measurement of heteronuclear one-bond coupling constants RSC Adv. 2016, 6, 87848-87855.
7	J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele Distinction of trans-cis photoisomers with comparable optical properties in multiple-state photochromic systems – Examining a molecule with three azobenzenes via in situ irradiation NMR Chem. Commun. 2016, 52, 12506-12509.
8	E. Procházková, A. Kolmer, J. Ilgen, M. Schwab, L. Kaltschnee, M. Fredersdorf, V. Schmidts, R. C. Wende, P. R. Schreiner, C. M. Thiele Uncovering Key Structural Features of an Enantioselective Peptide-Catalyzed Acylation Utilizing Advanced NMR Techniques Angew. Chem. 2016, 128, 15986–15991, Angew. Chem. Int. Ed. 2016, 55, 15754–15759.
9	J. Ilgen, L. Kaltschnee, C. M. Thiele A pure shift experiment with increased sensitivity and superior performance for strongly coupled systems J. Magn. Reson. 2018, 286, 18-29. [JMR Most-read Publication Award in 2018] [Raw Data: DOI 10.23728/b2share.76f2f9e3f53d4fce90e2ac768102c34e]
10	J. Ilgen, L. Kaltschnee, C. M. Thiele perfectBASH: Band-selective homonuclear decoupling in peptides and peptidomimetics Magn. Reson. Chem. 2018, 56, 918-933. [Raw Data: DOI 10.23728/b2share.688901f6e4fe4b92bd0238715c3186bb]
11	L. Kaltschnee, A. P. Jagtap, J. McCormick, S. Wagner, L.-S. Bouchard, M. Utz, C. Griesinger, S. Glöggler Hyperpolarization of Amino Acids in Water Utilizing Parahydrogen on a Rhodium Nanocatalyst Chem. Europ. J. 2019, 25, 11031–11035.
12	A. P. Jagtap, L. Kaltschnee, Stefan Glöggler Hyperpolarization of 15N-pyridinium and 15N-aniline derivatives by using parahydrogen: new opportunities to store nuclear spin polarization in aqueous media Chem. Sci. 2019, 10, 8577-8582.
13	J. Ilgen, J. Novag, L. Kaltschnee, V. Schmidts, C. M. Thiele Gradient selected pure shift EASY-ROESY techniques facilitate the quantitative measurement of 1H,1H-distance restraints in congested spectral regions J. Magn. Reson. 2021, 324, 106900-106911.
14	S. Yang, P. Saul, S. Mamone, L. Kaltschnee, S. Glöggler Bimodal Flourescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetime Chem. Europ. J. 2021, 28, e202104158.
15	S. Korchak, L. Kaltschnee, R. Dervisoglu, L. Andreas, C. Griesinger, Stefan Glöggler Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER Angew. Chem. Int. Ed. 2021, 60, 20984-20990.
16	L. Kaltschnee, A. N. Pravdivtsev, M. Gehl, G. Huang, G. L. Stoychev, C. Riplinger, M. Keitel, F. Neese, J.-B. Hövener, A. A. Auer, C. Griesinger, S. Shima, S. Glöggler Parahydrogen-enhanced magnetic resonance identification of intermediates in [Fe]-hydrogenase catalysis Nat. Catal 2024, 7, 1417-1429. DOI: 10.1038/s41929-024-01262-w
17	E. R. Cotroneo, T. C. Cheng, L. Kaltschnee, P. Maibach, M. Engelke, N. Schwegler, F. Thomas, C. M. Thiele, N. A. Simeth A Photoswitchable Tryptophan Zipper – (Un)folding Fibrils in Seconds preprint 2025, ChemRxiv, 2025. DOI: 10.26434/chemrxiv-2025-jclbt

Poster

1	L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Cross-relaxation rates from pure shift NOESY spectra EUROMAR 2012, Dublin/Ireland, 07/12.
2	A. Kolmer, L. Kaltschnee, M. Haus, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on dynamics and reactivity of Bis-NHC-complexes as observed by NMR spectroscopy EUROMAR 2012, Dublin/Ireland, 07/12.
3	L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Cross-relaxation rates from pure shift NOESY spectra GDCh FGMR 34th Annual Discussion Meeting, Halle, 09/12.
4	A. Kolmer, L. Kaltschnee, M. Haus, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on dynamics and reactivity of Bis-NHC-complexes as observed by NMR spectroscopy GDCh FGMR 34th Annual Discussion Meeting, Halle, 09/12.
5	L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Interatomic Distance Measurements Using Pure Shift NOE Experiments 54th Experimental Nuclear Magnetic Resonance Conference, Asilomar/California/USA, 04/13.
6	L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Interatomic Distance Measurements Using Pure Shift NOE Experiments EUROMAR 2013, Crete/Greece, 07/13.
7	L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling EUROMAR 2013, Crete/Greece, 07/13.
8	I. Timári, L. Kaltschnee, A. Kolmer, R. W. Adams, M. Nilsson, C. M. Thiele, G. A. Morris, K. E. Kövér Measuring one-bond heteronuclear coupling constants with improved resolution EUROMAR 2013, Crete/Greece, 07/13.
9	L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling GDCh FGMR 35th Discussion Meeting, Frauenchiemsee, 09/13.
10	L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling SMASH 2013, Santiago de Compostela/Spain, 09/13.
11	L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Applications of pure shift HSQC experiments with „perfectBIRD“ decoupling EUROMAR 2014, Zurich/Switzerland, 07/14.
12	Y. E. Moskalenko, V. Bagutski, L. Kaltschnee, C. M. Thiele PDMS Gels as Alignment Media for NMR/RDC Analysis of Small Organic Molecules ORCHEM 2014, Weimar, 09/14.
13	L. Kaltschnee, T. Imhof, K. Pulka-Ziach, Yu. E. Moskalenko, W. Bermel, C. M. Thiele Improving Signal Separation for Oligomeric Structures in Pure Shift HSQC Spectra EUROMAR 2015, Prague/Czech Republic, 07/15.
14	J. Ilgen, L. Kaltschnee, C. M. Thiele, A variant to Zangger-Sterk decoupling with improved sensitivity EUROMAR 2016, Aarhus/Denmark, 07/16.
15	J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele *Monitoring a Four-State Photoisomerization Process via In Situ* Irradiation NMR Spectroscopy** 5th Annual Practical Applications of NMR in Industry Conference (PANIC 2017), Hilton Head Island/SC/USA, 02/17.
16	J. Ilgen, L. Kaltschnee, C. M. Thiele A Zangger-Sterck based pure shift experiment not requiring full spatial separation of coupling partners for studies of peptidomimetic oligomers ENC 2017, Pacific Grove/CA/USA, 03/17.
17	J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele *Monitoring a Four-State Photoisomerization Process via In Situ* Irradiation NMR Spectroscopy** ENC 2017, Pacific Grove/CA/USA, 03/17.