- Medicinal chemistry of Alzheimer`s disease
Fluorescent probes for in vivo microscopy/ Alzheimer Diagnostics
Project presentation Deutsche Welle 13.2.2011 (min 3-8)
Podcast:
2 h HBO documentary on Alzheimer's disease research
- medicinal chemistry of:
hypertension: Angiotensin II receptor blocker
Alzheimer’s disease:: β-secretase inhibitors, β-secretase inhibitors, diagnostics, Tau Aggregation inhibitors, GSK3 inhibitors, fluorescent probes for Alzheimer diagnostic applications Parkinson’s disease Creutzfeld-Jacob disease: Prion aggregation inhibitors oncology: 20 S proteasome inhibitors
- multiparallel solid phase supported synthesis of non-peptidic lead structures
- selective aspartic protease modulators and inhibitors
- novel screening technologies
- drug metabolism
- reaction mechanisms: enantioselective reactions, metal-organic reactions
- protein-peptide interactions: beta-sheet aggregation
- heterocycle synthesis: novel heterocycles, green reactions
- novel reaction media: reactions in ionic liquids
- screening in fish
Current Reviews
- Bildung von Peptidfibrillen/Peptide fibrillization, Mehr erfahrenAngew. Chemie, 2007, 119, 8276
- B. Bulic, M. Pickhardt, B. Schmidt, E.M. Mandelkow, H. Waldmann, E. Mandelkow. Development of Tau Aggregation Inhibitors for Alzheimer's Disease Angew. Chem. Int. Ed. Engl, 2009, 48, 1740
