50) Schweipert, M., Nehls, T., Frühauf, A., Debarnot, C., Kumar, A., Knapp, S., Lermyte, F., Meyer-Almes, F.-J., The catalytic domain of free or ligand bound histone deacetylase 4 occurs in solution predominantly in closed conformation, Protein Science, 2024, 33, e4917
49) Schmidt, A., Zhang, H., Schmitt, S., Rausch, C., Popp, O., Chen, J., Cmarko, D, Butter, F., Dittmar, G., Lermyte, F., Cardoso, M.C., The Proteomic Composition and Organization of Constitutive Heterochromatin in Mouse Tissues, Cells, 2024, 13, 139
48) Geiger, T. M., Walz, M., Meyners, C., Kuehn, A., Dreizler, J. K., Sugiarto, W. O., Maciel, E., Zheng, M., Lermyte, F., Hausch, F., Discovery of a Potent PROTAC Enables Targeting of FKBP51’s Scaffolding Functions, Angewandte Chemie, 2024, 63, e202309706
47) Lermyte, F., The need for open and FAIR data in top-down proteomics, Proteomics, 2024, 24, 2300354
46) Habeck, T., Maciel, E. V. S., Kretschmer, K.,Lermyte, F., Charge site manipulation to enhance top‐down fragmentation efficiency, Proteomics, 2023, 2300082
45) Purder, P. L., Meyners, C., Sugiarto, W. O., Kolos, J., Löhr, F., Gebel, J., Nehls, T., Dötsch, V., Lermyte, F., Hausch, F., Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues, JACS Au, 2023, 3, 2478-2486
44) Brandner, S., Habeck, T.,Lermyte, F., New Insights into the Intrinsic Electron-Based Dissociation Behavior of Cytochrome c Oligomers, Journal of the American Society for Mass Spectrometry, 2023, 34, 1908-1916
43) Everett, J., Brooks, J., Lermyte, F., Tjhin, V. T., Hands-Portman, I., Hill, E., Collingwood, J. F.,Telling, N. D., Illuminating the brain: revealing brain biochemistry with synchrotron x-ray spectromicroscopy, Journal of Electron Spectroscopy and Related Phenomena, 2023, 147355
42) Schwickert, M., Zimmermann, R. A., Habeck, T., Hoba, S. N., Nidoieva, Z., Fischer, T. R., Stark, M. M., Kersten, C., Lermyte, F., Helm, M, Schirmeister, T., Covalent S-Adenosylhomocysteine-Based DNA Methyltransferase 2 Inhibitors with a New Type of Aryl Warhead, ACS Medicinal Chemistry Letters, 2023, 14, 777-787
41) Habeck, T., Lermyte, F., Seeing the complete picture: proteins in top-down mass spectrometry, Essays in Biochemistry, 2023, 67, 283-300
40) Nehls, T., Heymann, T., Meyners, C., Hausch, F., Lermyte, F., Fenton-Chemistry-Based Oxidative Modification of Proteins Reflects Their Conformation, International Journal of Molecular Sciences, 2021, 22, 9927
39) Imberti, C., Lermyte, F., Friar, E.P., O’Connor, P.B., Sadler, P.J., Facile protein conjugation of platinum for light-activated cytotoxic payload release, Chemical Communications, 2021, 57, 7645-7648
38) Everett, J., Lermyte, F., Brooks, J., Tjhin, V.T., Plascencia-Villa, G., Hands-Portman, I., Donnelly, J.M., Billimoria, K., Perry, G., Zhu, X., Sadler, P.J., O’Connor, P.B., Collingwood, J.F., Telling, N.T., Biogenic metallic elements in the human brain?, Science Advances, 2021, 7, eabf6707
37) Aliakbari, F., Mohammad-Beigi, H., Abbasi, S., Rezaei-Ghaleh, N., Lermyte, F., Parsafar, S., Becker, S., Tafreshi, A.P., O’Connor, P.B., Collingwood, J.F., Christiansen, G., Sutherland, D.S., Jensen, P.H., Morshedi, D., Otzen, D.E., Multiple Protective Roles of Nanoliposome‐Incorporated Baicalein against Alpha‐Synuclein Aggregates, Advanced Functional Materials, 2021, 31, 2007765
36) Lermyte, F., Theisen, A., O'Connor, P.B., Solution Condition-Dependent Formation of Gas-Phase Protomers of Alpha-Synuclein in Electrospray Ionization, Journal of the American Society for Mass Spectrometry, 2021, 32, 364
35) Donnelly, J.M., Lermyte, F., Wolny, J.A., Walker, M., Breeze, B.G., Needham, R.J., Müller, C.S., O'Connor, P.B., Schünemann, V., Collingwood, J.F., Sadler, P.J., Cu(III)–bis-thiolato complex forms an unusual mono-thiolato Cu(III)–peroxido adduct, Chemical Communications, 2021, 57, 69
34) Zhou, M., Lantz, C., Brown, K.A., Ge, Y., Pasa-Tolic, L., Loo, J.A., Lermyte, F., Higher-order structural characterisation of native proteins and complexes by top-down mass spectrometry, Chemical Science, 2020, 11, 12918
33) Anthony, E.J., Bolitho, E.M., Bridgewater, et al., Metallodrugs are unique: opportunities and challenges of discovery and development, Chemical Science, 2020, 11, 12888
32) Lermyte, F., Roles, Characteristics, and Analysis of Intrinsically Disordered Proteins: A Minireview, Life, 2020, 10, 320
31) Everett, J., Brooks, J., Lermyte, F., O'Connor, P.B., Sadler, P.J., Dobson, J., Collingwood, J.F., Telling, N.D., Iron stored in ferritin is chemically reduced in the presence of aggregating Aβ (1-42), Scientific Reports, 2020, 10, 10332
30) Brooks, J., Everett, J., Lermyte, F., Tjhin, V.T., Banerjee, S., O’Connor, P.B., Morris, C.M., Sadler, P.J., Telling, N.D., Collingwood, J.F., Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy, Journal of Trace Elements in Medicine and Biology, 2020, 62, 126555
29) Brooks, J., Everett, J., Lermyte, F., Tjhin, V.T., Banerjee, S., O’Connor, P.B., Morris, C.M., Sadler, P.J., Telling, N.D., Collingwood, J.F., Label‐free Nanoimaging of Neuromelanin in the Brain by Soft X‐ray Spectromicroscopy, Angewandte Chemie International Edition, 2020, 132(29), 12082-12089
28) Lermyte, F., Zhang, W.-Y., Brooks, J., Huband, S., Collingwood, J.F., Lees, M.R., Rayman, M.P., Sadler, P.J., Metallic iron in cornflakes, Food & Function, 2020, 11, 2938-2942
27) Marvian, A.T., Aliakbari, F., Mohammad-Beigi, H., Ahmadi, Z.A., Mehrpouvan, S., Lermyte, F., Nasouti, M., Collingwood, J.F., Otzen, D.E., Morshedi, D., The status of the terminal regions of α-synuclein in different forms of aggregates during fibrillization, International Journal of Biological Macromolecules, 2020, 155, 543-550
26) Williams, J.P., Morrison, L.J., Brown, J.M., Beckman, J.S., Voinov, V.G., Lermyte, F., Top-down characterisation of denatured proteins and native protein complexes using electron capture dissociation implemented within a modified ion mobility-mass spectrometer, Analytical Chemistry, 2020, 92(5), 3674-3681
25) Lam, Y.P.Y., Wotton, C.A., Hands-Portman, I., Wei, J., Chiu, C.K.C., Romero-Canelon, I., Lermyte, F., Barrow, M.P., O’Connor, P.B., Determination of the Aggregate Binding Site of Amyloid Protofibrils Using Electron Capture Dissociation Tandem Mass Spectrometry, Journal of the American Society for Mass Spectrometry, 2020, 31(2), 267-276
24) Lermyte, F., Everett, J., Brooks, J., Bellingeri, F., Billimoria, K., Sadler, P.J., O’Connor. P.B., Telling, N.T., Collingwood, J.F., Emerging Approaches to Investigate the Influence of Transition Metals in the Proteinopathies, Cells, 2019, 8(10), 1231
23) Lermyte, F., Dittwald, P., Claesen, J., Baggerman, G., Sobott, F., O’Connor, P.B., Laukens, K., Hooyberghs, J., Gambin, A., Valkenborg, D., MIND: A double-linear model to accurately determine monoisotopic precursor mass in high-resolution top-down proteomics, Analytical Chemistry, 2019, 91(15), 10310-10319
22) Lermyte, F., Everett, J., Lam, Y.P.Y., Wootton, C.A., Brooks, J., Barrow, M.P., Telling, N.D., Sadler, P.J., O’Connor, P.B., Collingwood, J.F., Metal ion binding to the amyloid ß monomer studied by native top-down FTICR mass spectrometry, Journal of the American Society for Mass Spectrometry, 2019, 30(10), 2123-2134
21) Lermyte, F., Tsybin, Y.O., O’Connor, P.B., Loo, J.A., Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches, Journal of the American Society for Mass Spectrometry, 2019, 30(7), 1149-1157
20) Banerjee, S., Omlor, A., Wolny, J.A., Han, Y., Lermyte, F., Godfrey, A.E., O’Connor, P.B., Schunemann, V., Danaie, M., Sadler, P.J., Generation of maghemite nanocrystals from iron–sulfur centres, Dalton Transactions, 2019, 48(26), 9564-9569
19) Łącki, M.K., Lermyte, F., Miasojedow, B., Startek, M.P., Sobott, F., Valkenborg, D., Gambin, A., masstodon: A tool for assigning peaks and modeling electron transfer reactions in top-down mass spectrometry, Analytical Chemistry, 2019, 91(3), 1801-1807
18) Lam, Y.P.Y., Wootton, C., Hands-Portman, I., Wei, J., Chiu, C.K.C., Romero-Canelon, I., Lermyte, F., Barrow, M.P., O'Connor, P.B., Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation? Chemical Communications, 2018, 54, 13853-13856
17) Ciach, M.A., Łącki, M.K., Miasojedow, B., Lermyte, F., Valkenborg, D., Sobott, F., Gambin, A., Estimation of Rates of Reactions Triggered by Electron Transfer in Top-Down Mass Spectrometry, Journal of Computational Biology, 2018, 25(3), 282-301
16) Lermyte, F., Valkenborg, D., Loo, J.A., Sobott, F., Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure, Mass Spectrometry Reviews, 2018, 37(6), 750-771
15) Polasky, D.A., Lermyte, F., Nshanian, M., Sobott, F., Andrews, P.C., Loo, J.A., Ruotolo, B.T., Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes, Analytical Chemistry, 2018, 90(4), 2756-2764
14) Everett, J., Collingwood, J.F., Tjendana-Tjhin, V., Brooks, J., Lermyte, F., Plascencia-Villa, G., Hands-Portman, I., Dobson, J., Perry, G., Telling, N.D., Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects, Nanoscale, 2018, 10, 11782-11796
13) Mrzic, A, Lermyte, F., Vu, T.N., Valkenborg, D., Laukens, K., InSourcerer: a high‐throughput method to search for unknown metabolite modifications by mass spectrometry, Rapid Communications in Mass Spectrometry, 2017, 31(17), 1396-1404
12) Takemori, N., Takemori, A., Wongkongkathep, P., Nshanian, M., Loo, R.R.O., Lermyte, F., Loo, J.A., Top-down/bottom-up mass spectrometry workflow using dissolvable polyacrylamide gels, Analytical Chemistry, 2017, 89(16), 8244-8250
11) Heirbaut, M., Lermyte, F., Martin, E.M., Beelen, S., Sobott, F., Strelkov, S.V., Weeks, S.D., Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1, Journal of Biological Chemistry, 2017, 292(24), 9944-9957
10) Lermyte, F., Sobott, F., A broader view on ion heating in traveling-wave devices using fragmentation of CsI clusters and extent of H˙ migration as molecular thermometers, Analyst, 2017, 142(18), 3388-3399
9) Lermyte, F., Łącki, M.K., Valkenborg, D., Gambin, A., Sobott, F., Conformational Space and Stability of ETD Charge Reduction Products of Ubiquitin, Journal of The American Society for Mass Spectrometry, 2017, 28(1), 69-76
8) Heirbaut, M., Lermyte, F., Martin, E.M., Beelen, S., Verschueren, T., Sobott, F., Strelkov, S.V., Weeks, S.D., The preferential heterodimerization of human small heat shock proteins HSPB1 and HSPB6 is dictated by the N-terminal domain, Archives of Biochemistry and Biophysics, 2016, 610, 41-50
7) Göth, M., Lermyte, F., Schmitt, X.J., Warnke, S., von Helden, G., Sobott, F., Pagel, K., Gas-phase microsolvation of ubiquitin: investigation of crown ether complexation sites using ion mobility-mass spectrometry, Analyst, 2016, 141(19), 5502-5510
6) Lermyte, F., Łącki, M.K., Valkenborg, D., Baggerman, G., Gambin, A., Sobott, F., Understanding reaction pathways in top-down ETD by dissecting isotope distributions: A mammoth task, International Journal of Mass Spectrometry, 2015, 390, 146-154
5) Lermyte, F., Verschueren, T., Brown, J.M., Williams, J.P., Valkenborg, D., Sobott, F., Characterization of top-down ETD in a travelling-wave ion guide, Methods, 2015, 89, 22-29
4) Claesen, J., Lermyte, F., Sobott, F., Burzykowski, T., Valkenborg, D., Differences in the Elemental Isotope Definition May Lead to Errors in Modern Mass-Spectrometry-Based Proteomics, Analytical Chemistry, 2015, 87(21), 10747-10754
3) Lermyte, F., Sobott, F., Electron transfer dissociation provides higher-order structural information of native and partially unfolded protein complexes, Proteomics, 2015, 15(16), 2813-2822
2) Lermyte, F. Williams, J.P., Brown, J.M., Martin, E.M., Sobott, F., Extensive Charge Reduction and Dissociation of Intact Protein Complexes Following Electron Transfer on a Quadrupole-Ion Mobility-Time-of-Flight MS, Journal of The American Society for Mass Spectrometry, 2015, 26(7), 1068-1076
1) Lermyte, F., Konijnenberg, A., Williams, J.P., Brown, J.M., Valkenborg, D, Sobott, F., ETD allows for native surface mapping of a 150 kDa noncovalent complex on a commercial Q-TWIMS-TOF instrument, Journal of The American Society for Mass Spectrometry, 2014, 25(3), 343-350
