Dr. Eliška Procházková
Working area(s)
Postdoc 01/16 - 12/16
Contact
Field of research
- NMR spectroscopy of organic molecules: nulceosides, nucleotides, peptides, viologens, azodyes, etc.
- structure determination and conformational analysis
- NMR parameters calculation
- molecular interactions
Education
| 02 – 06 | Secondary School, Masaryk Secondary School of Chemistry, Prague, CZ |
| 06 – 09 | Study of Biochemistry B. Sc., Faculty of Science, Charles University, Prague, CZ |
| 09 – 11 | Study of Biophysical Chemistry M. Sc., Faculty of Science, Charles University, Prague, CZ |
| 11 – 15 | Doctoral study of Physical Chemistry Ph. D., Faculty of Science, Charles University, Prague, CZ |
Bachelor thesis
| Title | The Life Cycle and Metabolic Pathways of the Etiological Agent of Malaria and the Design of a Potential Inhibitor of Hypoxanthin-Guanin-Xanthin-Phosphoribosyltransferase |
| Group | Prof. Dr. Antonín Holý |
| Place | Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, CZ |
Master thesis
| Title | Antioxidative Effects of the Analogues of Nucleic Acid Components |
| Group | Dr. Helena Mertlíková-Kaiserová |
| Place | Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prag, CZ |
Ph. D. thesis
| Title | The Structure and Properties of Modified Nucleic Acid Components |
| Group | Dr. Martin Dračínský |
| Place | Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prag, CZ |
Publications
| 1 |
H. Mertlíková-Kaiserová, M. Rumlová, E. Tloušťová, E. Procházková, A. Holý, I. Votruba Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG Biochem. Pharmacol. 2011, 82, 131-138. |
| 2 |
P. Jansa, O. Baszczyňski, E. Procházková, M. Dračínský, Z. Janeba Microwave-assisted hydrolysis of phosphonate diesters: an efficient protocol for the preparation of phosphonic acids Green Chem. 2012, 14, 2282-2288. |
| 3 |
E. Procházková, P. Jansa, M. Dračínský, A. Holý, H. Mertlíková-Kaiserová Determination of the antioxidative activity of substituted 5-aminopyrimidines Free Rad. Res. 2012, 46, 61-67. |
| 4 |
E. Procházková, P. Jansa, A. Březinová, L. Čechová, H. Mertlíková-Kaiserová, A. Holý, M. Dračínský Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening Bioorg. Med. Chem. Lett. 2012, 22, 6405-6409. |
| 5 |
E. Procházková, M. Šála, R. Nencka, M. Dračínský C6-substituted purine derivatives: an experimental and theoretical 1H, 13C and 15N NMR study Magn. Reson. Chem. 2012, 50, 181-186. |
| 6 |
E. Procházková, L. Čechová, P. Jansa, M. Dračínský Long-range heteronuclear coupling constants in 2,6-disubstituted purine derivatives Magn. Reson. Chem. 2012, 50, 295-298. |
| 7 |
M. Dračínský, E. Procházková, J. Kessler, J. Šebestík, P. Matějka, P. Bouř Resolution of Organic Polymorphic Crystals by Raman Spectroscopy J. Phys. Chem. B 2013, 117, 7297-7307. |
| 8 |
E. Procházková, L. Čechová, Z. Janeba, M. Dračínský A Switchable Intramolecular Hydrogen Bond in Polysubstituted 5-Nitrosopyrimidines J. Org. Chem. 2013, 78, 10121-10133. |
| 9 |
L. Čechová, E. Procházková, I. Císařová, M. Dračínský, Z. Janeba Separation of planar rotamers through intramolecular hydrogen bonding in polysubstituted 5-nitrosopyrimidines Chem. Commun. 2014, 50, 14892-14895. |
| 10 |
M. Dejmek, H. Hřebabecký, M. Šála, M. Dračínský, E. Procházková, P. Leyssen, J. Neyts, J. Balzarini, R. Nencka From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus Bioorg. Med. Chem. 2014, 22, 2974-2983. |
| 11 |
M. Dejmek, M. Šála, P. Plačková, H. Hřebabecký, L. Mascarell Borredà, J. Neyts, M. Dračínský, E. Procházková, P. Jansa, P. Leyssen, H. Mertlíková-Kaiserová, R. Nencka Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position Arch. Pharm. Chem. Life Sci. 2014, 347,478-485. |
| 12 |
M. M. Kaiser, D. Hocková, T.-H. Wang, M. Dračínský, L. Poštová-Slavětínská, E. Procházková, M. D. Edstein, M. Chavchich, D. T. Keough, L. W. Guddat, Z. Janeba Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases ChemMedChem 2014, 10, 1707-1723. |
| 13 |
M. Dejmek, M. Šála, H. Hřebabecký, M. Dračínský, E. Procházková, D. Chalupská, M. Klíma, P. Plačková, M. Hájek, G. Andrei, L. Naesens, P. Leyssen, J. Neyts, J. Balzarini, E. Boura, R. Nencka Norbornane-based nucleoside and nucleotide analogues locked in North conformation Bioorg. Med. Chem. 2014, 23, 184-191. |
| 14 |
I. Mejdrová, D. Chalupská, M. Kögler, M. Šála, P. Plačková, A. Baumlová, H. Hřebabecký, E. Procházková, M. Dejmek, R. Guillon, D. Strunin, J. Weber, G. Lee, G. Birkus, H. Mertlíková-Kaiserová, E. Boura, R. Nencka Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action J. Med. Chem. 2015, 58, 3767–3793. |
| 15 |
M. Šála, M. Dejmek, E. Procházková, H. Hřebabecký, J. Rybáček, M. Dračínský, P. Novák, Š. Rosenbergová, I. Rosenberg, R. Nencka A New Analogue of Locked Cyclohexane Nucleic Acids Synthesis 2015, 47, 2654-2662. |
| 16 |
M. Dračínský, L. Čechová, P. Hodgkinson, E. Procházková, Z. Janeba Resonance-assisted stabilisation of hydrogen bonds probed by NMR spectroscopy and path integral molecular dynamics Chem. Commun. 2015, 51, 13986-13989. |
| 17 |
H. Hřebabecký, E. Procházková, M. Šála, P. Plačková, E. Tloušťová, O. Barauskas, Y. J. Lee, Y. Tian, R. Mackman, R. Nencka Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides Org. Biomol. Chem. 2015, 13, 9300-9313. |
| 18 |
M. Šála, M. Dejmek, E. Procházková, H. Hřebabecký, J. Rybáček, M. Dračínský, P. Novák, Š. Rosenbergová, J. Fukal, V. Sychrovský, I. Rosenberg, R. Nencka Synthesis of locked cyclohexene and cyclohexane nucleic acids (LCeNA and LCNA) with modified adenosine units Org. Biomol. Chem. 2015, 13, 2703-2715. |
| 19 |
E. Procházková, L. Čechová, J. Tarábek, Z. Janeba, M. Dracinsky Tunable push–pull interactions in 5-nitrosopyrimidines J. Org. Chem. 2016, 81, 3780–3789. |
| 20 |
M. Šála, M. Kögler, P. Plačková, I. Mejdrová, H. Hřebabecký, E. Procházková, D. Strunin, G. Lee, G. Birkus, J. Weber, H. Mertlíková-Kaiserová, R. Nencka Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors Bioorg. Med. Chem. Lett. 2016, 26, 2706–2712. |
| 21 |
E. Procházková, A. Kolmer, J. Ilgen, M. Schwab, L. Kaltschnee, M. Fredersdorf, V. Schmidts, R. C. Wende, P. R. Schreiner, C. M. Thiele Uncovering Key Structural Features of an Enantioselective Peptide-Catalyzed Acylation Utilizing Advanced NMR Techniques Angew. Chem. 2016, 128, 15986–15991, Angew. Chem. Int. Ed. 2016, 55, 15754–15759. |
| 22 |
I. Mejdrová, D. Chalupská, P. Plačková, C. Müller, M. Šála, M. Klíma, A. Baumlová, H. Hřebabecký, E. Procházková, M. Dejmek, D. Strunin, J. Weber, G. Lee, M. Matoušová, H. Mertlíková-Kaiserová, J. Ziebuhr, G. Birkus, E. Boura, R. Nencka Rational design of novel highly potent and selective phosphatidylinositol 4-kinase IIIβ (PI4KB) inhibitors as broad-spectrum antiviral agents and tools for chemical biology J. Med. Chem. 2016, 60, 100-118. |
| 23 |
H. Hřebabecký, M. Dračínský, E. Procházková, M. Šála, R. Mackman, R. Nencka Control of α/β Anomer Formation by a 2′,5′ Bridge: Toward Nucleoside Derivatives Locked in the South Conformation J. Org. Chem. 2017, 82, 11337-11347. |
| 24 |
K. Bártová, L. Čechová, E. Procházková, O. Socha, Z. Janeba, M. Dračínský Influence of Intramolecular Charge Transfer and Nuclear Quantum Effects on Intramolecular Hydrogen Bonds in Azopyrimidines J. Org. Chem. 2017, 82, 10350-10359. |
| 25 |
E. Procházková, L. Čechová, J. Kind, Z. Janeba, C. M. Thiele, M. Dračínský Photoswitchable intramolecular hydrogen bonds in 5-phenylazopyrimidines revealed by in-situ irradiation NMR spectroscopy Chem. Eur. J. 2018, 24, 492-498. |
| 26 |
L. Iannazzo, M. Fonvielle, E. Braud, H. Hřebabecký, E. Procházková, R. Nencka, C. Mathé, M. Arthurc, M. Etheve-Quelquejeu Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes Org. Biomol. Chem. 2018, 16, 1903-1911. |
| 27 |
L. Čechová, J. Kind, M. Dračínský, J. Filo, Z. Janeba, C. M. Thiele, M. Cigáň, E. Procházková Photoswitching behavior of 5-phenylazopyrimidines: in situ irradiation NMR and optical spectroscopy combined with theoretical methods J. Org. Chem. 2018, 83, 5986-5998. |
