Dr. Eliška Procházková

Former members of the Thiele group

Dr. Eliška Procházková

Working area(s)

Postdoc 01/16 - 12/16

Contact

Field of research

NMR spectroscopy of organic molecules: nulceosides, nucleotides, peptides, viologens, azodyes, etc.
structure determination and conformational analysis
NMR parameters calculation
molecular interactions

Education

02 – 06	Secondary School, Masaryk Secondary School of Chemistry, Prague, CZ
06 – 09	Study of Biochemistry B. Sc., Faculty of Science, Charles University, Prague, CZ
09 – 11	Study of Biophysical Chemistry M. Sc., Faculty of Science, Charles University, Prague, CZ
11 – 15	Doctoral study of Physical Chemistry Ph. D., Faculty of Science, Charles University, Prague, CZ

Bachelor thesis

Title	The Life Cycle and Metabolic Pathways of the Etiological Agent of Malaria and the Design of a Potential Inhibitor of Hypoxanthin-Guanin-Xanthin-Phosphoribosyltransferase
Group	Prof. Dr. Antonín Holý
Place	Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, CZ

Master thesis

Title	Antioxidative Effects of the Analogues of Nucleic Acid Components
Group	Dr. Helena Mertlíková-Kaiserová
Place	Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prag, CZ

Ph. D. thesis

Title	The Structure and Properties of Modified Nucleic Acid Components
Group	Dr. Martin Dračínský
Place	Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prag, CZ

Publications

1	H. Mertlíková-Kaiserová, M. Rumlová, E. Tloušťová, E. Procházková, A. Holý, I. Votruba Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG Biochem. Pharmacol. 2011, 82, 131-138.
2	P. Jansa, O. Baszczyňski, E. Procházková, M. Dračínský, Z. Janeba Microwave-assisted hydrolysis of phosphonate diesters: an efficient protocol for the preparation of phosphonic acids Green Chem. 2012, 14, 2282-2288.
3	E. Procházková, P. Jansa, M. Dračínský, A. Holý, H. Mertlíková-Kaiserová Determination of the antioxidative activity of substituted 5-aminopyrimidines Free Rad. Res. 2012, 46, 61-67.
4	E. Procházková, P. Jansa, A. Březinová, L. Čechová, H. Mertlíková-Kaiserová, A. Holý, M. Dračínský Compound instability in dimethyl sulphoxide, case studies with 5-aminopyrimidines and the implications for compound storage and screening Bioorg. Med. Chem. Lett. 2012, 22, 6405-6409.
5	E. Procházková, M. Šála, R. Nencka, M. Dračínský C6-substituted purine derivatives: an experimental and theoretical 1H, 13C and 15N NMR study Magn. Reson. Chem. 2012, 50, 181-186.
6	E. Procházková, L. Čechová, P. Jansa, M. Dračínský Long-range heteronuclear coupling constants in 2,6-disubstituted purine derivatives Magn. Reson. Chem. 2012, 50, 295-298.
7	M. Dračínský, E. Procházková, J. Kessler, J. Šebestík, P. Matějka, P. Bouř Resolution of Organic Polymorphic Crystals by Raman Spectroscopy J. Phys. Chem. B 2013, 117, 7297-7307.
8	E. Procházková, L. Čechová, Z. Janeba, M. Dračínský A Switchable Intramolecular Hydrogen Bond in Polysubstituted 5-Nitrosopyrimidines J. Org. Chem. 2013, 78, 10121-10133.
9	L. Čechová, E. Procházková, I. Císařová, M. Dračínský, Z. Janeba Separation of planar rotamers through intramolecular hydrogen bonding in polysubstituted 5-nitrosopyrimidines Chem. Commun. 2014, 50, 14892-14895.
10	M. Dejmek, H. Hřebabecký, M. Šála, M. Dračínský, E. Procházková, P. Leyssen, J. Neyts, J. Balzarini, R. Nencka From norbornane-based nucleotide analogs locked in South conformation to novel inhibitors of feline herpes virus Bioorg. Med. Chem. 2014, 22, 2974-2983.
11	M. Dejmek, M. Šála, P. Plačková, H. Hřebabecký, L. Mascarell Borredà, J. Neyts, M. Dračínský, E. Procházková, P. Jansa, P. Leyssen, H. Mertlíková-Kaiserová, R. Nencka Synthesis of Novel Purine-Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N-9 Position Arch. Pharm. Chem. Life Sci. 2014, 347,478-485.
12	M. M. Kaiser, D. Hocková, T.-H. Wang, M. Dračínský, L. Poštová-Slavětínská, E. Procházková, M. D. Edstein, M. Chavchich, D. T. Keough, L. W. Guddat, Z. Janeba Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases ChemMedChem 2014, 10, 1707-1723.
13	M. Dejmek, M. Šála, H. Hřebabecký, M. Dračínský, E. Procházková, D. Chalupská, M. Klíma, P. Plačková, M. Hájek, G. Andrei, L. Naesens, P. Leyssen, J. Neyts, J. Balzarini, E. Boura, R. Nencka Norbornane-based nucleoside and nucleotide analogues locked in North conformation Bioorg. Med. Chem. 2014, 23, 184-191.
14	I. Mejdrová, D. Chalupská, M. Kögler, M. Šála, P. Plačková, A. Baumlová, H. Hřebabecký, E. Procházková, M. Dejmek, R. Guillon, D. Strunin, J. Weber, G. Lee, G. Birkus, H. Mertlíková-Kaiserová, E. Boura, R. Nencka Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action J. Med. Chem. 2015, 58, 3767–3793.
15	M. Šála, M. Dejmek, E. Procházková, H. Hřebabecký, J. Rybáček, M. Dračínský, P. Novák, Š. Rosenbergová, I. Rosenberg, R. Nencka A New Analogue of Locked Cyclohexane Nucleic Acids Synthesis 2015, 47, 2654-2662.
16	M. Dračínský, L. Čechová, P. Hodgkinson, E. Procházková, Z. Janeba Resonance-assisted stabilisation of hydrogen bonds probed by NMR spectroscopy and path integral molecular dynamics Chem. Commun. 2015, 51, 13986-13989.
17	H. Hřebabecký, E. Procházková, M. Šála, P. Plačková, E. Tloušťová, O. Barauskas, Y. J. Lee, Y. Tian, R. Mackman, R. Nencka Synthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides Org. Biomol. Chem. 2015, 13, 9300-9313.
18	M. Šála, M. Dejmek, E. Procházková, H. Hřebabecký, J. Rybáček, M. Dračínský, P. Novák, Š. Rosenbergová, J. Fukal, V. Sychrovský, I. Rosenberg, R. Nencka Synthesis of locked cyclohexene and cyclohexane nucleic acids (LCeNA and LCNA) with modified adenosine units Org. Biomol. Chem. 2015, 13, 2703-2715.
19	E. Procházková, L. Čechová, J. Tarábek, Z. Janeba, M. Dracinsky Tunable push–pull interactions in 5-nitrosopyrimidines J. Org. Chem. 2016, 81, 3780–3789.
20	M. Šála, M. Kögler, P. Plačková, I. Mejdrová, H. Hřebabecký, E. Procházková, D. Strunin, G. Lee, G. Birkus, J. Weber, H. Mertlíková-Kaiserová, R. Nencka Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors Bioorg. Med. Chem. Lett. 2016, 26, 2706–2712.
21	E. Procházková, A. Kolmer, J. Ilgen, M. Schwab, L. Kaltschnee, M. Fredersdorf, V. Schmidts, R. C. Wende, P. R. Schreiner, C. M. Thiele Uncovering Key Structural Features of an Enantioselective Peptide-Catalyzed Acylation Utilizing Advanced NMR Techniques Angew. Chem. 2016, 128, 15986–15991, Angew. Chem. Int. Ed. 2016, 55, 15754–15759.
22	I. Mejdrová, D. Chalupská, P. Plačková, C. Müller, M. Šála, M. Klíma, A. Baumlová, H. Hřebabecký, E. Procházková, M. Dejmek, D. Strunin, J. Weber, G. Lee, M. Matoušová, H. Mertlíková-Kaiserová, J. Ziebuhr, G. Birkus, E. Boura, R. Nencka Rational design of novel highly potent and selective phosphatidylinositol 4-kinase IIIβ (PI4KB) inhibitors as broad-spectrum antiviral agents and tools for chemical biology J. Med. Chem. 2016, 60, 100-118.
23	H. Hřebabecký, M. Dračínský, E. Procházková, M. Šála, R. Mackman, R. Nencka Control of α/β Anomer Formation by a 2′,5′ Bridge: Toward Nucleoside Derivatives Locked in the South Conformation J. Org. Chem. 2017, 82, 11337-11347.
24	K. Bártová, L. Čechová, E. Procházková, O. Socha, Z. Janeba, M. Dračínský Influence of Intramolecular Charge Transfer and Nuclear Quantum Effects on Intramolecular Hydrogen Bonds in Azopyrimidines J. Org. Chem. 2017, 82, 10350-10359.
25	E. Procházková, L. Čechová, J. Kind, Z. Janeba, C. M. Thiele, M. Dračínský *Photoswitchable intramolecular hydrogen bonds in 5-phenylazopyrimidines revealed by in-situ* irradiation NMR spectroscopy** Chem. Eur. J. 2018, 24, 492-498.
26	L. Iannazzo, M. Fonvielle, E. Braud, H. Hřebabecký, E. Procházková, R. Nencka, C. Mathé, M. Arthurc, M. Etheve-Quelquejeu Synthesis of tRNA analogues containing a terminal ribose locked in the South conformation to study tRNA-dependent enzymes Org. Biomol. Chem. 2018, 16, 1903-1911.
27	L. Čechová, J. Kind, M. Dračínský, J. Filo, Z. Janeba, C. M. Thiele, M. Cigáň, E. Procházková Photoswitching behavior of 5-phenylazopyrimidines: in situ irradiation NMR and optical spectroscopy combined with theoretical methods J. Org. Chem. 2018, 83, 5986-5998.