Dr. Lukas Kaltschnee
Arbeitsgebiet(e)
Masterthesis 10/11 - 04/12, Promotion 06/12 - 08/16, Postdoc 01/24 -
Kontakt
lkaltschnee@thielelab.de
work +49 6151 16-21836
Work
L207 5
Peter-Grünberg Straße 16
64287
Darmstadt
Forschungsgebiet
- Charakterisierung von Stofftransport nahe Dreiphasenkontaktlinien mittels MRT (Teilprojekt A08 im SFB 1194 „Wechselseitige Beeinflussung von Transport- und Benetzungsvorgängen“)
- Untersuchung von Wasserstoffkatalyse mittels Parawasserstoff-verstärkter NMR
Ausbildung & akademischer Werdegang
| seit 01/24 | Postdoc, Technische Universität Darmstadt, Darmstadt, im Rahmen des SFB 1194 |
| 09/17 – 01/24 | Postdoc, Max-Planck-Institut für Mulitdisziplinäre Naturwissenschaften (ehem. Max-Planck-Institut für Biophysikalische Chemie), Göttingen, bei Stefan Glöggler und Christian Griesinger |
| 09/16 – 08/17 | Postdoc, NIDDK/NIH, Bethesda, MD, USA, bei Adriaan Bax |
| 07/14 – 09/14 | Forschungsaufenthalt, University of Manchester, Großbrittanien, bei Gareth A. Morris |
| 06/12 – 08/16 | Promotion, Technische Universität Darmstadt, Darmstadt |
| 10/11 – 04/12 | Master-Thesis, Technische Universität Darmstadt, Darmstadt |
| 06/11 – 09/11 | Externe Hauptvertiefung, Max-Planck-Institut für Polymerforschung, Mainz, bei F. Laquai |
| 04/10 – 04/12 |
Chemiestudium M. Sc., Technische Universität Darmstadt, Darmstadt Schwerpunktfach Physikalische Chemie |
| 09/08 – 07/09 | ERASMUS-Auslandsstudium, École Polytechnique Fédérale de Lausanne, Lausanne (Schweiz) |
| 10/06 – 03/10 | Chemiestudium B. Sc., Technische Universität Darmstadt, Darmstadt |
| 09/05 – 05/06 | Zivildienst, Frankfurter Verein für soziale Heimstätten e.V. |
| 08/96 – 07/05 | Gymnasialer Zweig, Philipp-Reis-Schule, Friedrichsdorf |
| 08/92 – 07/96 | Grundschule, Frankfurt a. M. und Friedrichsdorf |
Bachelorthesis
| Titel | Effect of Coadsorbents on the Performance of Dye Sensitized Solar Cells |
| Arbeitskreis | Prof. Dr. M. Grätzel |
| Ort | Faculté des Sciences de Base, École Polytechnique Fédérale de Lausanne; eingereicht am Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt |
Masterthesis
| Titel | Untersuchungen zur Quantifizierung 1H-entkoppelter protonendetektierter Experimente |
| Arbeitskreis | Prof. Dr. C. M. Thiele |
| Ort | Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Fachbereich Chemie, Technische Universität Darmstadt |
Dissertation
| Titel | Development and Evaluation of Experiments for Pure Shift Solution-State Magnetic Resonance Spectroscopy |
| Arbeitskreis | Prof. Dr. C. M. Thiele |
| Ort | Clemens-Schöpf-Institut für Organische Chemie und Biochemie, Fachbereich Chemie, Technische Universität Darmstadt |
Preise und Auszeichnungen
| 01/13 – 12/14 | Promotionsstipendium der Merck'schen Gesellschaft für Kunst und Wissenschaft e.V. |
| 09/16 – 02/18 | P.R.I.M.E. Fellowship des Deutschen Akademischen Auslandsdienstes (DAAD) |
| 02/17 | Kurt-Ruths-Preis der Technischen Universität Darmstadt |
| 06/17 | Promotionspreis der Familie Bottling-Stiftung |
Vorträge
| 1 |
Improving Signal Separation for Oligomeric Structures in Pure Shift HSQC Spectra GDCh FGMR 37th Annual Discussion Meeting, Darmstadt, 09/15. (upgraded poster) |
| 2 |
CLIP-COSY: Rapid Acquisition of COSY-Type Correlation Spectra with In-Phase Signal Character 5th Annual Practical Applications of NMR in Industry Conference (PANIC 2017), Hilton Head Island/SC/USA, 02/17. (invited talk) |
| 3 |
Hydrogen catalysis of the [Fe]-hydrogenase studied by parahydrogen enhanced NMR Konstantin Ivanov Intercontinental Magnetic Resonance Seminar, online, 05/23. |
| 4 |
Hydrogen catalysis of the [Fe]-hydrogenase studied by parahydrogen enhanced NMR Kolloquium des Clemens-Schöpf-Instituts für?Organische Chemie und Biochemie, Technische Universität Darmstadt, 06/23. |
Publikationen
| 1 |
A. Kolmer, L. Kaltschnee, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on rotational barriers of bis-NHC-complexes as observed by dynamic NMR spectroscopy Magn. Reson. Chem. 2013, 51, 695–700. |
| 2 |
I. Timári, L. Kaltschnee, A. Kolmer, R. W. Adams, M. Nilsson, C. M. Thiele, G. A. Morris, K. E. Kövér Accurate determination of one-bond heteronuclear coupling constants with “pure shift” broadband proton-decoupled CLIP/CLAP-HSQC experiments J. Magn. Reson. 2014, 239, 130-138. |
| 3 |
L. Kaltschnee, A. Kolmer, I. Timári, V. Schmidts, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele „Perfecting“ pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings Chem. Commun. 2014, 50, 15702-15705. |
| 4 |
M. R. M. Koos, G. Kummerlöwe, L. Kaltschnee, C. M. Thiele, B. Luy CLIP-COSY: A Clean Inphase Experiment for Rapid Acquisition of COSY-type Correlations Angew. Chem. 2016, 128, 7785-7789, Angew. Chem. Int. Ed. 2016, 55, 7655-7659. |
| 5 |
L. Kaltschnee, K. Knoll, V. Schmidts, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Extraction of Distance Restraints from Pure Shift NOE experiments J. Magn. Reson. 2016, 271, 99-109. |
| 6 |
I. Timári, L. Kaltschnee, M. H. Raics, F. Roth, N. G. A. Bell, R. W. Adams, M. Nilsson, D. Uhrín, G. A. Morris, C. M. Thiele, K. E. Kövér Real-time broadband proton-homodecoupled CLIP/CLAP-HSQC for automated measurement of heteronuclear one-bond coupling constants RSC Adv. 2016, 6, 87848-87855. |
| 7 |
J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele Distinction of trans-cis photoisomers with comparable optical properties in multiple-state photochromic systems – Examining a molecule with three azobenzenes via in situ irradiation NMR Chem. Commun. 2016, 52, 12506-12509. |
| 8 |
E. Procházková, A. Kolmer, J. Ilgen, M. Schwab, L. Kaltschnee, M. Fredersdorf, V. Schmidts, R. C. Wende, P. R. Schreiner, C. M. Thiele Uncovering Key Structural Features of an Enantioselective Peptide-Catalyzed Acylation Utilizing Advanced NMR Techniques Angew. Chem. 2016, 128, 15986–15991, Angew. Chem. Int. Ed. 2016, 55, 15754–15759. |
| 9 |
J. Ilgen, L. Kaltschnee, C. M. Thiele A pure shift experiment with increased sensitivity and superior performance for strongly coupled systems J. Magn. Reson. 2018, 286, 18-29. [JMR Most-read Publication Award in 2018] [Raw Data: DOI 10.23728/b2share.76f2f9e3f53d4fce90e2ac768102c34e] |
| 10 |
J. Ilgen, L. Kaltschnee, C. M. Thiele perfectBASH: Band-selective homonuclear decoupling in peptides and peptidomimetics Magn. Reson. Chem. 2018, 56, 918-933. [Raw Data: DOI 10.23728/b2share.688901f6e4fe4b92bd0238715c3186bb] |
| 11 |
L. Kaltschnee, A. P. Jagtap, J. McCormick, S. Wagner, L.-S. Bouchard, M. Utz, C. Griesinger, S. Glöggler Hyperpolarization of Amino Acids in Water Utilizing Parahydrogen on a Rhodium Nanocatalyst Chem. Europ. J. 2019, 25, 11031–11035. |
| 12 |
A. P. Jagtap, L. Kaltschnee, Stefan Glöggler Hyperpolarization of 15N-pyridinium and 15N-aniline derivatives by using parahydrogen: new opportunities to store nuclear spin polarization in aqueous media Chem. Sci. 2019, 10, 8577-8582. |
| 13 |
J. Ilgen, J. Novag, L. Kaltschnee, V. Schmidts, C. M. Thiele Gradient selected pure shift EASY-ROESY techniques facilitate the quantitative measurement of 1H,1H-distance restraints in congested spectral regions J. Magn. Reson. 2021, 324, 106900-106911. |
| 14 |
S. Yang, P. Saul, S. Mamone, L. Kaltschnee, S. Glöggler Bimodal Flourescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetime Chem. Europ. J. 2021, 28, e202104158. |
| 15 |
S. Korchak, L. Kaltschnee, R. Dervisoglu, L. Andreas, C. Griesinger, Stefan Glöggler Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER Angew. Chem. Int. Ed. 2021, 60, 20984-20990. |
| 16 |
L. Kaltschnee, A. N. Pravdivtsev, M. Gehl, G. Huang, G. L. Stoychev, C. Riplinger, M. Keitel, F. Neese, J.-B. Hövener, A. A. Auer, C. Griesinger, S. Shima, S. Glöggler Sensitivity-enhanced magnetic resonance reveals hydrogen intermediates during active [Fe]-hydrogenase catalysis preprint 2023, bioRxiv doi: 10.1101/2023.05.10.540199. |
Poster
| 1 |
L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Cross-relaxation rates from pure shift NOESY spectra EUROMAR 2012, Dublin/Ireland, 07/12. |
| 2 |
A. Kolmer, L. Kaltschnee, M. Haus, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on dynamics and reactivity of Bis-NHC-complexes as observed by NMR spectroscopy EUROMAR 2012, Dublin/Ireland, 07/12. |
| 3 |
L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Cross-relaxation rates from pure shift NOESY spectra GDCh FGMR 34th Annual Discussion Meeting, Halle, 09/12. |
| 4 |
A. Kolmer, L. Kaltschnee, M. Haus, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on dynamics and reactivity of Bis-NHC-complexes as observed by NMR spectroscopy GDCh FGMR 34th Annual Discussion Meeting, Halle, 09/12. |
| 5 |
L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Interatomic Distance Measurements Using Pure Shift NOE Experiments 54th Experimental Nuclear Magnetic Resonance Conference, Asilomar/California/USA, 04/13. |
| 6 |
L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Interatomic Distance Measurements Using Pure Shift NOE Experiments EUROMAR 2013, Crete/Greece, 07/13. |
| 7 |
L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling EUROMAR 2013, Crete/Greece, 07/13. |
| 8 |
I. Timári, L. Kaltschnee, A. Kolmer, R. W. Adams, M. Nilsson, C. M. Thiele, G. A. Morris, K. E. Kövér Measuring one-bond heteronuclear coupling constants with improved resolution EUROMAR 2013, Crete/Greece, 07/13. |
| 9 |
L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling GDCh FGMR 35th Discussion Meeting, Frauenchiemsee, 09/13. |
| 10 |
L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling SMASH 2013, Santiago de Compostela/Spain, 09/13. |
| 11 |
L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Applications of pure shift HSQC experiments with „perfectBIRD“ decoupling EUROMAR 2014, Zurich/Switzerland, 07/14. |
| 12 |
Y. E. Moskalenko, V. Bagutski, L. Kaltschnee, C. M. Thiele PDMS Gels as Alignment Media for NMR/RDC Analysis of Small Organic Molecules ORCHEM 2014, Weimar, 09/14. |
| 13 |
L. Kaltschnee, T. Imhof, K. Pulka-Ziach, Yu. E. Moskalenko, W. Bermel, C. M. Thiele Improving Signal Separation for Oligomeric Structures in Pure Shift HSQC Spectra EUROMAR 2015, Prague/Czech Republic, 07/15. |
| 14 |
J. Ilgen, L. Kaltschnee, C. M. Thiele, A variant to Zangger-Sterk decoupling with improved sensitivity EUROMAR 2016, Aarhus/Denmark, 07/16. |
| 15 |
J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele Monitoring a Four-State Photoisomerization Process via In Situ Irradiation NMR Spectroscopy 5th Annual Practical Applications of NMR in Industry Conference (PANIC 2017), Hilton Head Island/SC/USA, 02/17. |
| 16 |
J. Ilgen, L. Kaltschnee, C. M. Thiele A Zangger-Sterck based pure shift experiment not requiring full spatial separation of coupling partners for studies of peptidomimetic oligomers ENC 2017, Pacific Grove/CA/USA, 03/17. |
| 17 |
J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele Monitoring a Four-State Photoisomerization Process via In Situ Irradiation NMR Spectroscopy ENC 2017, Pacific Grove/CA/USA, 03/17. |
