Lukas Kaltschnee – Thiele Lab – TU Darmstadt

The Thiele group

Dr. Lukas Kaltschnee

Working area(s)

Master thesis 10/11 - 04/12, Ph.D. 06/12 - 08/16, Postdoc 01/24 -

Contact

lkaltschnee@thielelab.de

work +49 6151 16-21836

Work L207 5
Peter-Grünberg Straße 16
64287 Darmstadt

Field of research

Characterization of mass transport near three-phase contact lines using MRI (Project A08 im CRC 1194 „Interaction between Transport and Wetting Processes“)
investigation of hydrogen catalysis with para-hydrogen enhanced NMR

Education & academic career

08/92 – 07/96	Elementary school, Frankfurt a. M. and Friedrichsdorf
08/96 – 07/05	Secondary school, Philipp-Reis-Schule, Friedrichsdorf
09/05 – 05/06	Civilian service, Frankfurter Verein für soziale Heimstätten e.V.
10/06 – 03/10	Study of Chemistry B. Sc., Technische Universität Darmstadt, Darmstadt
09/08 – 07/09	Studies abroad (ERASMUS exchange program), École Polytechnique Fédérale de Lausanne, Lausanne (Switzerland)
04/10 – 04/12	Study of Chemistry M. Sc., Technische Universität Darmstadt, Darmstadt Major field of study: Physical Chemistry
06/11 – 09/11	External research project, Max-Planck-Institut für Polymerforschung, Mainz, with F. Laquai
10/11 – 04/12	Master thesis, Technische Universität Darmstadt, Darmstadt
06/12 – 08/16	Ph. D. studies, Technische Universität Darmstadt, Darmstadt
07/14 – 09/14	Visiting scientist, University of Manchester, UK, with Gareth A. Morris
09/16 – 08/17	Postdoc, NIDDK/NIH, Bethesda, MD, USA, with Adriaan Bax
09/17 – 01/24	Postdoc, Max-Planck-Institut für Mulitdisziplinäre Naturwissenschaften (prev. Max-Planck-Institut für Biophysikalische Chemie), Göttingen, with Stefan Glöggler and Christian Griesinger
since 01/24	Postdoc, Technische Universität Darmstadt, Darmstadt, within CRC 1194

Bachelor thesis

Title	Effect of Coadsorbents on the Performance of Dye Sensitized Solar Cells
Group	Prof. Dr. M. Grätzel
Place	Faculté des Sciences de Base, École Polytechnique Fédérale de Lausanne; handed in at the Eduard-Zintl-Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt

Master thesis

Title	Untersuchungen zur Quantifizierung 1H-entkoppelter protonendetektierter Experimente
Group	Prof. Dr. C. M. Thiele
Place	Department of Chemistry, Technical University Darmstadt

Dissertation

Title	Development and Evaluation of Experiments for Pure Shift Solution-State Magnetic Resonance Spectroscopy
Group	Prof. Dr. C. M. Thiele
Place	Department of Chemistry, Technical University Darmstadt

Prizes and awards

01/13 – 12/14	Ph. D. fellowship of the Merck'sche Gesellschaft für Kunst und Wissenschaft e.V.
09/16 – 02/18	P.R.I.M.E. Fellowship awarded by the German Academic Exchange Service (DAAD)
02/17	Kurt-Ruths-Award at Technische Universität Darmstadt
06/17	Graduation stipend of the Family Bottling Foundation 2017

Talks

1	Improving Signal Separation for Oligomeric Structures in Pure Shift HSQC Spectra GDCh FGMR 37th Annual Discussion Meeting, Darmstadt, 09/15. (upgraded poster)
2	CLIP-COSY: Rapid Acquisition of COSY-Type Correlation Spectra with In-Phase Signal Character 5th Annual Practical Applications of NMR in Industry Conference (PANIC 2017), Hilton Head Island/SC/USA, 02/17. (invited talk)

Publications

1	A. Kolmer, L. Kaltschnee, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on rotational barriers of bis-NHC-complexes as observed by dynamic NMR spectroscopy Magn. Reson. Chem. 2013, 51, 695–700.
2	I. Timári, L. Kaltschnee, A. Kolmer, R. W. Adams, M. Nilsson, C. M. Thiele, G. A. Morris, K. E. Kövér Accurate determination of one-bond heteronuclear coupling constants with “pure shift” broadband proton-decoupled CLIP/CLAP-HSQC experiments J. Magn. Reson. 2014, 239, 130-138.
3	L. Kaltschnee, A. Kolmer, I. Timári, V. Schmidts, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele “Perfecting” pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings Chem. Commun. 2014, 50, 15702-15705.
4	M. R. M. Koos, G. Kummerlöwe, L. Kaltschnee, C. M. Thiele, B. Luy CLIP-COSY: A Clean Inphase Experiment for Rapid Acquisition of COSY-type Correlations Angew. Chem. 2016, 128, 7785-7789, Angew. Chem. Int. Ed. 2016, 55, 7655-7659.
5	L. Kaltschnee, K. Knoll, V. Schmidts, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Extraction of Distance Restraints from Pure Shift NOE experiments J. Magn. Reson. 2016, 271, 99-109.
6	I. Timári, L. Kaltschnee, M. H. Raics, F. Roth, N. G. A. Bell, R. W. Adams, M. Nilsson, D. Uhrín, G. A. Morris, C. M. Thiele, K. E. Kövér Real-time broadband proton-homodecoupled CLIP/CLAP-HSQC for automated measurement of heteronuclear one-bond coupling constants RSC Adv. 2016, 6, 87848-87855.
7	J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele Distinction of trans-cis photoisomers with comparable optical properties in multiple-state photochromic systems – Examining a molecule with three azobenzenes via in situ irradiation NMR Chem. Commun. 2016, 52, 12506-12509.
8	E. Procházková, A. Kolmer, J. Ilgen, M. Schwab, L. Kaltschnee, M. Fredersdorf, V. Schmidts, R. C. Wende, P. R. Schreiner, C. M. Thiele Uncovering Key Structural Features of an Enantioselective Peptide-Catalyzed Acylation Utilizing Advanced NMR Techniques Angew. Chem. 2016, 128, 15986–15991, Angew. Chem. Int. Ed. 2016, 55, 15754–15759.
9	J. Ilgen, L. Kaltschnee, C. M. Thiele A pure shift experiment with increased sensitivity and superior performance for strongly coupled systems J. Magn. Reson. 2018, 286, 18-29. [JMR Most-read Publication Award in 2018] [Raw Data: DOI 10.23728/b2share.76f2f9e3f53d4fce90e2ac768102c34e]
10	J. Ilgen, L. Kaltschnee, C. M. Thiele perfectBASH: Band-selective homonuclear decoupling in peptides and peptidomimetics Magn. Reson. Chem. 2018, 56, 918-933. [Raw Data: DOI 10.23728/b2share.688901f6e4fe4b92bd0238715c3186bb]
11	L. Kaltschnee, A. P. Jagtap, J. McCormick, S. Wagner, L.-S. Bouchard, M. Utz, C. Griesinger, S. Glöggler Hyperpolarization of Amino Acids in Water Utilizing Parahydrogen on a Rhodium Nanocatalyst Chem. Europ. J. 2019, 25, 11031–11035.
12	A. P. Jagtap, L. Kaltschnee, Stefan Glöggler Hyperpolarization of 15N-pyridinium and 15N-aniline derivatives by using parahydrogen: new opportunities to store nuclear spin polarization in aqueous media Chem. Sci. 2019, 10, 8577-8582.
13	J. Ilgen, J. Novag, L. Kaltschnee, V. Schmidts, C. M. Thiele Gradient selected pure shift EASY-ROESY techniques facilitate the quantitative measurement of 1H,1H-distance restraints in congested spectral regions J. Magn. Reson. 2021, 324, 106900-106911.
14	S. Yang, P. Saul, S. Mamone, L. Kaltschnee, S. Glöggler Bimodal Flourescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetime Chem. Europ. J. 2021, 28, e202104158.
15	S. Korchak, L. Kaltschnee, R. Dervisoglu, L. Andreas, C. Griesinger, Stefan Glöggler Spontaneous Enhancement of Magnetic Resonance Signals Using a RASER Angew. Chem. Int. Ed. 2021, 60, 20984-20990.
16	L. Kaltschnee, A. N. Pravdivtsev, M. Gehl, G. Huang, G. L. Stoychev, C. Riplinger, M. Keitel, F. Neese, J.-B. Hövener, A. A. Auer, C. Griesinger, S. Shima, S. Glöggler Sensitivity-enhanced magnetic resonance reveals hydrogen intermediates during active [Fe]-hydrogenase catalysis preprint 2023, bioRxiv doi: 10.1101/2023.05.10.540199.

Poster

1	L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Cross-relaxation rates from pure shift NOESY spectra EUROMAR 2012, Dublin/Ireland, 07/12.
2	A. Kolmer, L. Kaltschnee, M. Haus, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on dynamics and reactivity of Bis-NHC-complexes as observed by NMR spectroscopy EUROMAR 2012, Dublin/Ireland, 07/12.
3	L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Cross-relaxation rates from pure shift NOESY spectra GDCh FGMR 34th Annual Discussion Meeting, Halle, 09/12.
4	A. Kolmer, L. Kaltschnee, M. Haus, V. Schmidts, L. H. Peeck, H. Plenio, C. M. Thiele The influence of electronic modifications on dynamics and reactivity of Bis-NHC-complexes as observed by NMR spectroscopy GDCh FGMR 34th Annual Discussion Meeting, Halle, 09/12.
5	L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Interatomic Distance Measurements Using Pure Shift NOE Experiments 54th Experimental Nuclear Magnetic Resonance Conference, Asilomar/California/USA, 04/13.
6	L. Kaltschnee, V. Schmidts, J. A. Aguilar, A. A. Colbourne, R. W. Adams, M. Nilsson, G. A. Morris, C. M. Thiele Interatomic Distance Measurements Using Pure Shift NOE Experiments EUROMAR 2013, Crete/Greece, 07/13.
7	L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling EUROMAR 2013, Crete/Greece, 07/13.
8	I. Timári, L. Kaltschnee, A. Kolmer, R. W. Adams, M. Nilsson, C. M. Thiele, G. A. Morris, K. E. Kövér Measuring one-bond heteronuclear coupling constants with improved resolution EUROMAR 2013, Crete/Greece, 07/13.
9	L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling GDCh FGMR 35th Discussion Meeting, Frauenchiemsee, 09/13.
10	L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Pure Shift HSQC measurements with perfectBIRD decoupling SMASH 2013, Santiago de Compostela/Spain, 09/13.
11	L. Kaltschnee, A. Kolmer, I. Timári, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris, C. M. Thiele Applications of pure shift HSQC experiments with „perfectBIRD“ decoupling EUROMAR 2014, Zurich/Switzerland, 07/14.
12	Y. E. Moskalenko, V. Bagutski, L. Kaltschnee, C. M. Thiele PDMS Gels as Alignment Media for NMR/RDC Analysis of Small Organic Molecules ORCHEM 2014, Weimar, 09/14.
13	L. Kaltschnee, T. Imhof, K. Pulka-Ziach, Yu. E. Moskalenko, W. Bermel, C. M. Thiele Improving Signal Separation for Oligomeric Structures in Pure Shift HSQC Spectra EUROMAR 2015, Prague/Czech Republic, 07/15.
14	J. Ilgen, L. Kaltschnee, C. M. Thiele, A variant to Zangger-Sterk decoupling with improved sensitivity EUROMAR 2016, Aarhus/Denmark, 07/16.
15	J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele *Monitoring a Four-State Photoisomerization Process via In Situ* Irradiation NMR Spectroscopy** 5th Annual Practical Applications of NMR in Industry Conference (PANIC 2017), Hilton Head Island/SC/USA, 02/17.
16	J. Ilgen, L. Kaltschnee, C. M. Thiele A Zangger-Sterck based pure shift experiment not requiring full spatial separation of coupling partners for studies of peptidomimetic oligomers ENC 2017, Pacific Grove/CA/USA, 03/17.
17	J. Kind, L. Kaltschnee, M. Leyendecker, C. M. Thiele *Monitoring a Four-State Photoisomerization Process via In Situ* Irradiation NMR Spectroscopy** ENC 2017, Pacific Grove/CA/USA, 03/17.